Treatment of EARLY DIABETES

Early Diabetes: Definition, Present Concept.- Early Diabetes. Concept. Terminology.- Early Stages of Diabetes: Definitions and Present Concepts.- Prediabetes in the Pima Indians.- The Prognosis of Insulin Dependent Diabetes Mellitus and the Importance of Supervision.- Discussion.- Genetic Influences on Islet Cell Function.- HLA System.- HLA and the Genetic Aspects of the Predisposition to Juvenile Diabetes Mellitus. A Follow-Up.- HLA Studies in Diabetics.- Discussion.- Familial Patterns of Inheritance.- On the Genetic Heterogeneity of Juvenile Hyperglycemia.- Familial Patterns of Inheritance of Diabetes Mellitus. Maturity-Onset Type Diabetes of Young People (MODY).- Discussion.- Metabolic Aspects of Islet Cell Function.- Phosphate Translocations During Secretory Stimulation of Pancreatic Islets.- The Role of Phosphoenolpyruvate and Lactate Production in Insulin Secretion.- Effects of Insulinotropic Agents on Cationic Fluxes in Islet Cells.- Glucose-Induced Changes of the Membrane Potential of Pancreatic B-Cells: Their Significance for the Regulation of Insulin Release.- Discussion.- Abnormal Development of the Pancreas.- Effect of Maternal Carbohydrate Intolerance on the Development of the Autonomic Innervation of the Fetal Rat Pancreas.- Discussion.- Environmental Factors Influencing Islet Cell Function.- Nutritional.- Suppression of Insulin Secretion by Protein Deprivation in Obesity.- Discussion.- Viruses.- Virus-Induced Diabetes Mellitus: Infection of Mice with Variants of Encephalomyocarditis Virus, Coxsackievirus B4, and Reovirus Type 3.- Autoimmunity.- Immunological Aspects of Diabetes Mellitus.- Detection and Possible Functional Influence of Antibodies Directed Against the Pancreatic Islet Cell Surface.- Discussion.- Patterns of Insulin Secretion.- Heterogeneityof Insulin Responses in Maturity-Onset Type Diabetes (MOD) and in Maturity-Onset Type Diabetes of Young People (MODY).- Progression of Early Diabetes.- Insulin Resistance and Insulin Secretion in Patients with Chemical Diabetes: Implications Concerning the Pathogenesis of Idiopathic Diabetes Mellitus.- Inquiries into the Pathogenesis of Gestational Diabetes.- Effect of Intravenous Glucose, Leucine and Arginine on Concentration of Insulin in Maternal and Umbilical Cord Serum.- Discussion.- Mechanism of Salvaging Beta Cell Function.- Beta Cell Dysfunction in Maturity-Onset Diabetes: Reversible Loss of Glucose-Induced Insulin Secretion with Retention of Response to Arginine.- Improvement of Insulin Secretion in Diabetics by a Prostaglandin Synthesis Inhibitor.- Discussion.- Diet Therapy.- Decreased Food Intake.- Effect of Diet Limitation on Development of Diabetes in Non-Hyperphagic Prediabetic Chinese Hamsters.- Riboflavin in CHO Metabolism.- The Role of Riboflavin in Carbohydrate Metabolism.- Discussion.- Responses to Different Complex Carbohydrates.- Effect of Variations in Carbohydrate Intake on Plasma Glucose, Insulin and Triglyceride Responses in Normal Subjects and Patients with Chemical Diabetes.- High Carbohydrate, High Fiber Diets for Patients with Diabetes.- Dietary Fiber and Diabetic Therapy: A Progressive Effect with Time.- Discussion.- High Myoinositol.- Dietary myo-Inositol and Diabetic Neuropathy.- Discussion.- Long Term Treatment with Insulin.- Animals.- Effect of Insulin Treatment on the Mesangial Structure of KK Mice.- Humans.- Insulin Treatment for Adult Onset Diabetes: A Report of the University Group Diabetes Program.- Refuting the UGDP Conclusion That Insulin Treatment Does Not Prevent Vascular Complications in Diabetes.- Discussion.- New Insulins.-New Synthetic Insulins.- Differential Response of Insulin-Dependent Diabetics to Infusions of Bovine and Highly-Purified Porcine Insulins: A Preliminary Report.- Discussion.- Enzyme Inhibitors.- Delay of Carbohydrate Absorption by Inhibitors of Intestinal ?-Glucosidases.- Inhibition of Polyol Pathway Activity in Diabetic and Galactosemic Rats by the Aldose Reductase Inhibitor CP-45,634.- Discussion.- Mechanism of Action of Oral Compounds.- Genetic Control of Tolbutamide Metabolism in Humans.- Insulin Resistance in Patients with Insulin Independent Diabetes Mellitus: Partial Amelioration by the Sulfonylurea Glipizide.- Discussion.- Long Term Treatment with Oral Compounds.- Animals.- Diabetic Glomerulosclerosis in KK Mice and Its Prevention by Glyburide and Pyridinolcarbamate.- Discussion.- Humans.- Long Term Treatment of Asymptomatic Diabetes.- Metabolic Fate, Vascular Outcome and the Effect of Treatment in Borderline Diabetics.- Long-Term Treatment of Subjects with Borderline Glucose Tolerance.- Discussion.- New Oral Agents: Comparisons.- Glipizide: A New Second Generation Sulfonylurea.- Effect of the Oral Hypoglycemic Agent Pirogliride Tartrate on Insulin and Glucagon Secretion In Vivo and In Vitro.- Gliclazide in the Treatment of Diabetic Retinopathy.- Discussion.- Exercise.- The Effect of Repetitive Exercise on Daily Control of Glycemia in Insulin-Dependent Diabetic Patients.- Discussion.- Substitution of Islet Cell Function.- Transplant.- Isolation and Preservation In Vitro of Human Pancreatic Islets Intended for Transplantation.- The Development, Enhancement and Reversibility of Diabetic Glomerulopathy.- Discussion.- Newer Delivery Systems.- Substitution of Islet-Cell Function with “Open-Loop” Insulin Infusion Systems.- Newer Insulin Delivery Systems:Continuous Subcutaneous Insulin Infusion.- Discussion.- Mechanical Devices.- Substitution of Islet Cell Function by Mechanical Device: Extracorporeal Artificial Pancreas.- Glycemic Normalization Using a Preprogrammed Insulin Delivery Device in Unrestrained Diabetic Dogs.- Discussion.- List of Participants.