Advances in Cancer Research (eBook)
192 Seiten
Elsevier Science (Verlag)
978-0-08-048823-3 (ISBN)
The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents outstanding and original reviews on a variety of topics, including Mdm2 - a regulator of cell growth and death, the systematic progression of human cancer, seizing of T-cells by human T-cell leukemia/lymphoma virus type II, host cell dependent expression of latent Epstein-Barr virus genomes, and gene expression profiling of renal cell carcinoma and its implications in diagnosis prognosis and therapeutics.
The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents outstanding and original reviews on a variety of topics, including Mdm2 - a regulator of cell growth and death; the systematic progression of human cancer; seizing of T-cells by human T-cell leukemia/lymphoma virus type II; host cell dependent expression of latent Epstein-Barr virus genomes; and gene expression profiling of renal cell carcinoma and its implications in diagnosis prognosis and therapeutics. - Provides invaluable information on the exciting and fast-moving field of cancer research. - Presents outstanding and original reviews on a variety of topics, including Mdm2 - a regulator of cell growth and death; the systematic progression of human cancer; seizing of T-cells by human T-cell leukemia/lymphoma virus type II; host cell dependent expression of latent Epstein-Barr virus genomes; and gene expression profiling of renal cell carcinoma and its implications in diagnosis prognosis and therapeutics
Cover 1
Contents 6
Contributors to Volume 89 8
Chapter 1. Mdm2: A Regulator of Cell Growth and Death 10
I. The Mdm2 Oncogene 10
II. Epilogue 31
References 32
Chapter 2. The Systemic Progression of Human Cancer: A Focus on the Individual Disseminated Cancer Cell„The Unit of Selection 44
I. Concepts of Metastatic Progression 45
II. Premises and Compromises in the Study of Metastatic Progression 47
III. Direct Analysis of Links between Primary Tumors and Their Metastases 52
IV. The Evolution of Cancer Cells 58
V. Consequences for the Development of Systemic Therapies 68
Conclusions and Perspectives 70
References 71
Chapter 3. Seizing of T Cells by Human T-Cell Leukemia/Lymphoma Virus Type 1 78
I. Introduction 79
II. Human T-Cell Leukemia/Lymphoma Virus Type 1 (HTLV-1) 71 80
III. The HTLV-1 ORF IV 93
IV. The Effect of HTLV-1 on Cell Cycle Regulators 100
V. Overall HTLV-1- or Tax-Induced Transcription Profiles in T-Cells by DNA Microarray or Subtraction–Hybridization Techniques 106
VI. HTLV-1 Proteins Involved in in Vitro Oncognicity 111
VII. In Vivo Expansion of T-Cell Clones and Viral Latency 111
VIII. Adult T-Cell Leukemia/Lymphoma 113
IX. Summary 114
References 115
Chapter 4. Host Cell-Dependent Expression of Latent Epstein–Barr Virus Genomes: Regulation by DNA Methylation 142
I. Introduction 143
II. Forms of Epstein–Barr Virus Latency 144
III. Role of DNA Methylation in Cell Phenotype-Dependent Silencing of Latent EBV Promoters 150
IV. Mechanisms of Promoter Silencing by CpG Methylation 154
V. Methylation Patterns of OriP, the Latent Origin of EBV Replication 157
VI. Perspectives: The Coming Age of Epigenetics in Herpesvirus Research 159
References 160
Chapter 5. Gene Expression Profiling of Renal Cell Carcinoma and Its Implications in Diagnosis, Prognosis, and Therapeutics 166
I. Introduction 167
II. Microarray Studies 170
III. Clinical Implications in Diagnosis 172
IV. Clinical Implications in Prognosis 179
V. Clinical Implications in Therapy 183
VI. Future Microarray Studies in RCC 184
VII. Postmicroarray Studies 185
References 187
Index 192
| Erscheint lt. Verlag | 7.11.2003 |
|---|---|
| Mitarbeit |
Herausgeber (Serie): George Klein |
| Sprache | englisch |
| Themenwelt | Sachbuch/Ratgeber |
| Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie | |
| Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie | |
| Naturwissenschaften ► Biologie ► Zellbiologie | |
| Technik | |
| ISBN-10 | 0-08-048823-4 / 0080488234 |
| ISBN-13 | 978-0-08-048823-3 / 9780080488233 |
| Haben Sie eine Frage zum Produkt? |
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