Tyrosine Phosphorylation /Dephosphorylation and Downstream Signalling

This study unveils signal pathways that connect extracellular signals with changes in the phosphorylation state of target proteins, allowing the co-ordinated and integrated modulation of mitogenic signalling.

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Nearly every cellular activity, such as cell growth, proliferation, protein synthesis and nuclear division, is regulated by protein phosphorylation/dephosphorylation on tyrosine residues as initiation events. Synchronization occurs through the interaction of protein tyrosine kinases and phosphatases. This book unveils signal pathways that connect extracellular signals with changes in the phosphorylation state of target proteins, allowing the co-ordinated and integrated modulation of mitogenic signalling. Specifically, cascades involving protein serine/threonine kinases and connections to phosphoinositide-derived second messengers are discussed.