CCK (Cholecystokinin)

Professor Christine Feinle-Bisset has a PhD in Nutrition and GI Physiology from the University of Stuttgart-Hohenheim, Germany. After gaining research experience at the University of Sheffield, UK and the University of Zurich, Switzerland, she joined the University of Adelaide in 2000, where she is currently a Professorial Research Fellow and a lead investigator in the Centre of Research Excellence in Translating Nutritional Science to Good Health. Her research is clinical and relates to the impact of nutrients on appetite, GI motor and hormone function and perception, in health, obesity and functional dyspepsia. Her work has contributed significantly to current concepts of the role of gastrointestinal mechanisms, including gut hormones and gastrointestinal motor activity, in the regulation of energy intake in health and obesity, and symptom generation in functional dyspepsia. She has published more than 220 publications, with over 15,000 citations. Professor Jens F. Rehfeld has an MD from the University of Aarhus, and later DMSc and DSc in Clinical Biochemistry from the University of Copenhagen. He became professor in Medical Biochemistry at University of Aarhus in 1975, and of Clinical Biochemistry, University of Copenhagen, in 1981. He was also administrative head of the Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, until 2010. His main research theme is bioactive peptides (in particular gastrin, cholecystokinin, and insulin), their biosynthesis, methods for measurement, and clinical relevance. He has published approximately 1100 publications, including 650 original articles, 90 review articles, 55 textbook chapters, and 8 books, and has more than 43,000 citations.

Part I History 1. Milestones in the CCK history Part II Biology of CCK 2. The CCK phylogenesis - Including other animals (fish, starfish, other species) 3. CCK biogenesis and cell-specific expression of CCK peptides 4. CCK in intestinal and extraintestinal endocrine cells 5. CCK in cerebral and peripheral neurons 6. CCK1 and CCK2 receptors 7. The relationship of CCK and gastrin Part III Physiology of CCK 8. Intestinal CCK secretion 9. CCK and the vagus – gut-brain axis 10. CCK and the gallbladder 11. CCK and the exocrine pancreas (including pancreatitis, pancreatic cancer) 12. CCK and the endocrine pancreas, including T2 diabetes 13. CCK and GI motor function – oesophagus to colon 14. CCK and appetite/food intake 15. CCK and food/nutrient preferences (including conditioned flavour preferences) 16. CCK and nausea/taste aversion 17. CCK and peripheral and central cardiovascular control 18. CCK in cardiac myocytes, including cardiac diseases Part IV Methods used for CCK research 19. CCK in circulation and how it is measured 20. CCK knockout mice: peripheral and central phenotypes Part V CCK in disease 21. CCK in metabolic diseases 22. CCK and disorders of gut-brain interaction (DGBIs; functional dyspepsia, IBS) 23. CCK in tumors 24. CCK and fear/anxiety, cerebral disease 25. CCK and the immune system 26. CCK and nociception Part V CCK-based novel therapeutic approaches 27. CCK and potential novel therapeutics Part VI Conclusion 28. Future directions for CCK research