Animal Models of Disease Part B

Lorenzo Galluzzi is Assistant Professor of Cell Biology in Radiation Oncology at the Department of Radiation Oncology of the Weill Cornell Medical College, Honorary Assistant Professor Adjunct with the Department of Dermatology of the Yale School of Medicine, Honorary Associate Professor with the Faculty of Medicine of the University of Paris, and Faculty Member with the Graduate School of Biomedical Sciences and Biotechnology of the University of Ferrara, the Graduate School of Pharmacological Sciences of the University of Padova, and the Graduate School of Network Oncology and Precision Medicine of the University of Rome “La Sapienza”. Moreover, he is Associate Director of the European Academy for Tumor Immunology and Founding Member of the European Research Institute for Integrated Cellular Pathology. Galluzzi is best known for major experimental and conceptual contributions to the fields of cell death, autophagy, tumor metabolism and tumor immunology. He has published over 450 articles in international peer-reviewed journals and is the Editor-in-Chief of four journals: OncoImmunology (which he co-founded in 2011), International Review of Cell and Molecular Biology, Methods in Cell biology, and Molecular and Cellular Oncology (which he co-founded in 2013). Additionally, he serves as Founding Editor for Microbial Cell and Cell Stress, and Associate Editor for Cell Death and Disease, Pharmacological Research and iScience. Fernando Aranda holds a BSc in Biology (2006) and Biochemistry (2007) from the University of Navarra. Then, he specialized in different strategies of Cancer Immunotherapy with a MSc in Biomedical Research (2008), and a PhD Degree (2012) from the University of Navarra (Pamplona) – Cima University of Navarra. More than 12 years in translational research focus on antitumor immune responses and Cancer Immunotherapy. Author of 64 publications indexed in PubMed in prestigious international journals, with h-index 30 and 4,296 cites (October 2022). He completed the Program of Sara Borrell (ISCIII) -competitive Postdoctoral contract- in the Group of Immune Receptors of the Innate and Adaptive System (IDIBAPS), Barcelona (2016-2018). Co-author of 1 invention patent: Composition based on the fibronectin domain A for the treatment of melanoma - WO/2011/101332. In 2012, Fernando Aranda obtained a Scientific Award, "Profesor Durantez" II Edición, for the best scientific article in Tumor Immunology by Fundación LAIR. Recently, Fernando Aranda awarded a competitive Research Fellow contract “Miguel Servet tipo I” by Instituto de Salud Carlos III, to continue his independent researcher career (IP) in cancer immunotherapy issues. Specifically, he is involved in Translational Immunotherapy of Peritoneal Carcinomatosis. Currently, Fernando Aranda leads a research group in cooperation with Dr. Pedro Berraondo. Aitziber Buqué is currently a Post-Doctoral Associate with the Galluzzi Lab, in the Department of Radiation Oncology at Weill Cornell Medical College (New York), where she investigates innate and acquired mechanisms of resistance to immunotherapy in HR+ breast cancer and radiotherapy as a means to overcome them. Prior to joining the Galluzzi Lab (2018), Aitziber was a Post-Doctoral Associate with the Kroemer Lab in the Cordeliers Research Center (Paris, France; 2014-2018), after receiving her M.Sc. in Bioinformatics and Computational Biology (2006) from the Complutense University (Madrid, Spain) and her Ph.D. in Biomedicine (2013) from the BioCruces Research Institute (Barakaldo, Spain). Aitziber has a long-standing interest in the immunological mechanisms controlling cancer progression and response to treatment. Jose Manuel Bravo-San Pedro is currently a researcher at the Department of Physiology of the Complutense University of Madrid thanks to a Ramon y Cajal contract grant. He got his Ph.D. in biochemistry, cellular biology and genetics from the University of Extremadura (Caceres, Spain) in 2011, and he did a post-doctoral stage in the laboratory of Prof. Guido Kroemer. His main research interests have always been linked to autophagy, addressing this cellular process associated with neurodegenerative diseases or cancer and recently obesity and specifically related to problems in the correct functioning of the cilium. He is co-inventor of two patents and co-author of 110 publications indexed in PubMed in prestigious international journals, with h-index 45 and 23768 cites (Dec 2022).

Preface Lorenzo Galluzzi, Fernando Aranda Vega, Aitziber Buque Martinez and Jose Manuel Bravo-San Pedro

1. Using C. elegans as a model for neurodegenerative diseases: Methodology and evaluation Elena Caldero-Escudero, Silvia Romero-Sanz and Sergio De la Fuente

2. Animal model of multiple sclerosis: Experimental autoimmune encephalomyelitis Ana Muñoz-Jurado, Begoña Escribano and Isaac Túnez

3. A new procedure to induce aortic aneurysms in mice Raquel Rodrigues-Díez, Antonio Tejera-Muñoz and Raúl R. Rodrigues-Diez

4. Spinal nerve ligation: An experimental model to study neuropathic pain in rats and mice Erick J. Rodríguez-Palma, Itzel I. Ramos-Rodríguez, Saúl Huerta de la Cruz, Vinicio Granados-Soto and Maria Sancho

5. Identifying therapeutic compounds for autosomal dominant optic atrophy (ADOA) through screening in the nematode C. elegans Fivos Borbolis and Konstantinos Palikaras

6. Eµ-TCL1 adoptive transfer mouse model of chronic lymphocytic leukemia Iria Fernandez Botana, Susanne Gonder, Vanessa Klapp, Etienne Moussay and Jerome Paggetti

7. Purification and characterization of kidney-infiltrating leukocytes in a mouse model of lupus nephritis Laura Amo, Hemanta K. Kole, Bethany Scott, Francisco Borrego, Chen-Feng Qi, Hongsheng Wang and Silvia Bolland

8. Differences in intratumor innate lymphoid cell composition between orthotopic and spontaneous pancreatic mouse models Sara Lamorte, Alisha R. Elford, Douglas C. Chung, Kiichi Murakami, Tracy L. McGaha and Nicolas Jacquelot

9. Assessing motor development and function in mouse models of neurodevelopmental disorders Lauren Dierdorff, Marta Garcia-Forn, Alexa von Mueffling and Silvia De Rubeis

10. Analysis of the gut microbiota profile targeted to multiple hypervariable regions of 16S rRNA in a hypertensive heart failure rat model Javier Modrego, Adriana Ortega-Hernández, Silvia Sánchez-González, Arturo Corbatón-Anchuelo and Dulcenombre Gómez-Garre

11. Animal models of neglected parasitic diseases: In vivo multimodal imaging of experimental trypanosomatid infections Jean Marc Tsagmo Ngoune, Brice Rotureau and Estefanía Calvo Alvarez

12. Intracranial graft of bioresorbable polymer scaffolds loaded with human dental pulp stem cells in stab wound murine injury model Irene Manero-Roig, Yurena Polo, Beatriz Pardo-Rodríguez, Jon Luzuriaga, Ruth Basanta-Torres, Daniel Martín-Aragón, Irene Romayor, Sara Martín-Colomo, Joana Márquez, Laura Gomez-Santos, Frédéric Lanore, Yann Humeau, Gaskon Ibarretxe, Cristina Eguizabal, Aitor Larrañaga and Jose Ramon Pineda