Sliding Filament Mechanism in Muscle Contraction

Sliding Filament Mechanism at the Molecular Level.- Early Developments in Muscle Research and the Role of New Structural Technologies.- The Molecular Basis of Cross-Bridge Function.- Molecular Synchronization in Actomyosin Motors — From Single Molecule to Muscle Fiber Via Nanomuscle.- Distribution of Crossbridge States in Contracting Muscle.- X-Ray Diffraction Studies of Striated Muscles.- Conformational Change and Regulation of Myosin Molecules.- Mechanism of Muscle Contraction.- Driving Filament Sliding: Weak binding cross-bridge states, strong binding cross-bridge states, and the power stroke.- Mysteries about Amplitude and Efficiency of Cross-Bridge Powerstroke.- Sarcomere Dynamics, Stepwise Shortening and the Nature of Contraction.- Crossbridge Formation Detected by Stiffness Measurements in Single Muscle Fibres.- Non Cross-Bridge Stiffness in Skeletal Muscle Fibres at Rest and During Activity.- Nature’s Strategy for Optimizing Power Generation in Insect Flight Muscle.- Muscle Energetics.- From Crossbridges to Metabolism: System Biology for Energetics.- Energetics, Mechanics and Molecular Engineering of Calcium Cycling in Skeletal Muscle.- Heat, Phosphorus NMR and Microcalorimetry in Relation to the Mechanism of Filament Sliding.- How Two-Foot Molecular Motors May Walk.- Regulatory Mechanism and E-C Coupling.- Molecular Basis of Calcium Regulation of Striated Muscle Contraction.- Mechanisms of Calcium Release from the Sarcoplasmic Reticulum in Skeletal Muscle.- From Inward Spread of Activation, Active Elongation to the Effect of Organic Calcium Channel Blockers in Muscle Excitation-Contraction Coupling.- Cardiac and Smooth Muscle.- Cardiac Myosin Binding Protein C: Modulator of Contractility.- Human Atrial Myosin Light Chain 1 Expression Attenuates HeartFailure.- Cytoplasmic Free Concentrations of Ca2+ in Skeletal Muscle Cells.- Mysterious Beauty of Beating Heart: Cardiac mechano-energetico-informatics.- Is Myosin Phosphorylation Sufficient to Regulate Smooth Muscle Contraction?.- Other Aspects.- Comparative Aspects of Crossbridge Function — Skinned Fibre Studies.- Dynamic Structures of Myosin, Kinesin and Troponin as Detected by SDSL-ESR.- Mutations of Transcription Factors in Human with Heart Disease for Understanding the Development and Mechanisms of Congenital Cardiovascular Heart Disease.- General Discussion Part I Skeletal Muscle Mechanics.- General Discussion Part I Skeletal Muscle Mechanics.- General Discussion Part II Skeletal Muscle Energetics.- General Discussion Part II Skeletal Muscle Energetics.- General Discussion — Skeletal Muscle III Structural Studies.- General Discussion — Skeletal Muscle III Structural Studies.- General Discussion Part IV Cardiac Muscle.- General Discussion Part IV Cardiac Muscle.- General Discussion Part V Smooth Muscle.- General Discussion Part V Smooth Muscle.- Concluding Remarks.- Concluding Remarks.