Sustainable Quality Improvements for Isotope Dilution in Molecular Ultratrace Analyses

Yves Tondeur is the Founder and CEO of It’s About Purpose, LLC, based in the USA. He graduated from the Free University of Brussels with a Ph.D. in Chemistry. Post-doctoral research work in the field of analytical organic mass spectrometry entailed the applications of negative chemical ionization mass spectrometry to trace analyses of chlorinated aromatic compounds, interfacing the sample preparation and mass spectrometry laboratories while developing and optimizing analytical procedures for substances of concern. He developed the original version of USEPA Method 8290 in support of the Superfund Program before rejoining a group of former scientists and colleagues who founded a commercial laboratory. He consistently and determinatively promoted the benefits of isotope dilution for measuring trace levels of toxic compounds, refined the original version of Method 8290 leading to the analytical portion of Method 23 for stack emissions, and Method 1613. During his tenure at Analytical Perspectives, efforts toward improvements in methodologies continued with a special emphasis on understanding the technology, how it differentiates itself from older methods and other technologies, and how a genuine performance-based approach could be materialized.

1. Spotlight on the Issues
2. The Path to Current Reality
3. Quality Improvement Movements
4 Self-referential principle and enfolded performance concept
5. Quality-Generating Assays
6. Batch Control Spike
7. Performance-Based Criteria Analysis
8. Innovation Platform
9. Revisiting Traditions
10. The right, legal, and correct answers

Appendices
A: Guideposts for core steps
B: Limits of detection (LOD) and quantitation (LOQ)
C: Measurement of uncertainty
D: What’s our focus?
E: Audit samples — Method 301 PLQ — Method 23 final rule
F: Method 1668 validation study
G: New formation mechanism in secondary aluminum smelter
H: Insights into the origin of dioxins in ancient tertiary clays
I: Performance assessment—A vision
J: Method detection limits
K: Artifact and vigilance
L: LOQ validation
M: Percent valley
N: SQI-relevant definitions
O: SQI charts
P: Reference values

References
Reflections pool