Cervical Cancer: From Epidemiology and Diagnostics to Treatment and Surveillance

Chair of the Gynecologic Oncology Centre, General University Hospital of Charles University in Prague since 2003; president of the European Society of Gynecologic Oncology (ESGO) (2015–2017); founder and chair of the collaborative group in gynecologic oncology: Central and Eastern European Gynecologic Oncology Group (www.ceegog.eu); chair of the ESGO working group on Clinical Practice Guidelines in Cervical Cancer (2016–2022); chair of the Czech Society of Gynecologic Oncology; author or co-author of more than 350 peer-reviewed articles. David Cibula’s special interest has always been in cervical cancer. He has published dozens of scientific papers about the management of cervical cancer, served as the principal investigator of several academic international trials on the management of cervical cancer (SENTIX; ABRAX; CERVANTES; SCCAN), chaired international working groups (ESGO) on clinical practice guidelines and quality indicators on cervical cancer, and produced a popular series of instructional surgical films on radical surgery in gynecologic oncology.

1. Introduction

2. Global epidemiology, prevention, and ambitions for eradication

3. Diagnostics and clinical staging

4. Pathology

5. Critical appraisal of prognostic factors and models

6. Surgical treatment

6.1. Radical parametrectomy and lymphadenectomy technique and classification

6.2. Sentinel lymph node concept

6.3. Surgical management of early stages

6.4. Fertility-sparing management

6.5. Pelvic exenterations, LEER, and out-of-the-box procedures

6.6. Morbidity of surgery

7. Radiotherapy

7.1. Principles of radiotherapy

7.2. Role of adjuvant treatment in early stages

7.3. Primary chemoradiation in locally advanced disease

7.4. Radiotherapy in the management of isolated distant metastases and in palliation

7.5. Morbidity of radiotherapy

8. Systemic treatment

8.1. Primary metastatic disease

8.2. Recurrent disease

8.3. Toxicity of systemic treatment

9. Cervical cancer in pregnancy

10. Surveillance