The Enzymes

Laurie S. Kaguni is at Michigan State University, MI, USA Fuyu Tamanoi is a biochemist who has served on the UCLA School of Medicine and UCLA College faculty since he joined the Department of Microbiology, Immunology & Molecular Genetics in 1993. He became a full professor in 1997.

I. Introduction 1. History of The Enzymes Fuyuhiko Tamanoi, 2. Impact of The Enzymes in chronicling biochemical processes and pathways Laurie S. Kaguni

II. Metabolism and Catalysis 3. Mitochondrial ATP synthase John Walker 4. The respiratory chain Mårten Wikström 5. A century of mitochondrial research Howard Jacobs 6. Five decades of metalloenzymology Robert P. Hausinger 7. Mechanisms of catalysis Kenneth Allen Johnson 8. Mitochondrial fatty acid synthesis and associated processes Alexander Kastaniotis

III. Signaling 9. MAPK cascades: Origins, mechanisms and current status Jeremy Thorner 10. Sphingolipids: From structural components to signaling hubs Johnny Stiban and Saurav Majumder

IV. Protein Homeostasis and Hydrolysis 11. Mitochondrial AAA+ proteases Yuichi Matsushima 12. Hsp70 and JDP proteins: structure-function perspective on molecular chaperone activity Szymon Ciesielski

V. DNA Replication and Repair 13. Structure-function studies of DNA replication proteins Borja Ibarra 14. Helicases required for nucleotide excision repair Li Fan