Peptide and Protein Drug Delivery

Vincent Lee

"Fundamentals Changing Needs in Drug Delivery in the Era of Peptide and Protein Drugs Synthesis of Peptides and Proteins by Chemical and Biotechnological Means Physical Biochemistry of Peptide Drugs: Structure, Properties, and Stabilities of Peptides Compared with Proteins Physical Biochemistry of Protein Drugs Analysis of Peptide Drugs Analysis of Protein Drugs Enzymatic Barriers Intestinal Epithelial and Vascular Endothelial Barriers to Peptide and Protein Delivery Pharmacokinetics and Pharmacodynamics of Peptides Routes of Delivery Parenteral Routes of Peptide and Protein Drug Delivery Nasal Route of Peptide and Protein Drug Delivery Buccal Routes of Peptide and Protein Drug Delivery Oral Route of Peptide and Protein Drug Delivery Rectal Route of Peptide and Protein Drug Delivery Vaginal Route of Peptide and Protein Drug Delivery Transdermal Route of Peptide and Protein Drug Delivery Practical Considerations Preformulation and Formulation Considerations of Peptide Drugs: Case History of an LHRH Analog Mucosal Dosage Forms for Peptide and Protein Delivery Controlled Delivery Systems for Peptides Characterization of the Toxicity Profile of Peptide and Protein Therapeutics Reduction of Immunogenicity and Extension of Circulating Half-Life of Peptides and Proteins Regulatory Perspective of Peptide and Protein Drug Development "