Natural Products and their Bioactives in Antidiabetic Drug Discovery

Kanti Bhooshan Pandey, PhD, is a Senior Scientist and Assistant Professor in the Faculty of Biological Sciences, AcSIR; CSIR-Central Salt & Marine Chemicals Research Institute, Gujarat, India. Maitree Suttajit, PhD, is Professor Emeritus previously at School of Medicine, Chiang Mai University and later at School of Medical Sciences, University of Phayao, Thailand. Pinar Atukeren, PhD, is a senior Professor in Medical Biochemistry teaching in İstanbul Üniversitesi-Cerrahpaşa, Cerrahpaşa Faculty of Medicine, Department of Medical Biochemistry, and also the Founding Dean of İstanbul Üniversitesi-Cerrahpaşa, Faculty of Pharmacy, Turkey.

List of Contributors viii

Preface xii

Part I Fundamental Concepts of Diabetes Mellitus and Drug Discovery Process 1

1 Diabetes Mellitus and Natural Product-based Drug Discovery: Novel Directions 3
David J. Newman

2 Marine Natural Products in the Management of Diabetes Mellitus 18
Murali Krishna Paidi, Kanchan Siddaprasad Udata, and Subir Kumar Mandal

3 Carbohydrate-based Antidiabetic Agents from Natural Products 38
Sandeep Singh

4 Functional Foods in Clinical Trials in the Intervention of Diabetes Complications 49
Bavani Arumugam and Umah Rani Kuppusamy

5 Role of Nanotechnology in Refining the Antidiabetic Activities of Plant Derived Bioactives 74
Sonam Mishra, Ravindra Dhar, Maitree Suttajit, and Bishnu Kumar Pandey

Part II Bioactive Compounds Against Type 1 Diabetes Mellitus 97

6 Epidemiology and Genetics of Type 1 Diabetes Mellitus: The Effect of the Mediterranean Diet 99
Bilge Nur Col and Muveddet Emel Alphan

7 The Emerging Role of Plant Polyphenols in the Management of Type 1 Diabetes Mellitus 113
S. Asha Devi, Suparna Mandal, and S. Raja Sekhar

8 Bioactives as Modulators of β-cells and Immunity in Therapy of Type 1 Diabetes Mellitus 136
Shashank Kumar Ojha

9 Obesity in Type 1 Diabetes Mellitus: Clinical Impact and Nutritional Therapy 147
Gülen Ecem Kalkan and Burcu Ateş Özcan

10 Protective Effects of Natural Non-insulin Drugs against Type 1 Diabetes Mellitus 164
Waseem Hassan, Faraza Javaid, Andleeb Shahzadi, and Sahar Bakht

Part III Bioactive Compounds Against Type 2 Diabetes Mellitus 177

11 Age-induced Biomarkers of Oxidative Stress in Type 2 Diabetes Mellitus: Role of Plant Polyphenols 179
Brahm Kumar Tiwari and Kanti Bhooshan Pandey

12 Bioactives from Clove Oil for Antibacterial Wound Dressings for the Treatment and Management of Wounds in Type 2 Diabetes Mellitus 195
Andleeb Shahzadi and Haktan Sonmez

13 Nutritional Features and Bioactivities of Thymoquinone against Type 2 Diabetes Mellitus 211
Pınar Atukeren

14 Effect of Resveratrol and Catechins in Maintaining Redox Homeostasis during Type 2 Diabetes Mellitus 219
Prachee Dubey and Geeta Watal

15 Cannabis: Action Mechanisms and Potential Roles in the Management of Type 2 Diabetes Mellitus 232
Karolin Yanar and Zeynep Mine Coşkun Yazıcı

Part IV Gestational Diabetes: Prevention and Management by Natural Compounds 245

16 Epidemiology of Gestational Diabetes Mellitus: Preventive Significance of Dietary Pattern 247
Burcu Yeşilkaya

17 Biomarkers of Gestational Diabetes Mellitus, Dietary Polyphenols, and Drug Discovery 260
Mansi Gandhi

18 Medicinal and Aromatic Plants in the Prevention of Gestational Diabetes and Associated Consequences: Current Insights 275
Jigeesha Mishra, Kanti Bhooshan Pandey, and Shailendra Kumar Srivastava

19 Enhancement of Insulin Sensitivity and Management of Lipid Disorders during Gestational Diabetes Mellitus: Role of Capsaicin 294
Banu Orta-Yilmaz, Ahu Korkut, and Yasemin Aydin

20 Effects of Natural Products on the Genetics of Gestational Diabetes Mellitus 308
Onur Baykara

Index 321