Principles in Microbiome Engineering (eBook)

Matthew Chang is Associate Professor in Biochemistry in the Yong Loo Lin School of Medicine at the National University of Singapore (NUS), and Director of the Singapore Consortium for Synthetic Biology (SINERGY), Wilmar-NUS Corporate Laboratory (Wil-NUS) and NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI). His research interests lie in the development of biological systems that perform programmable functions. In particular, he has pioneered the development of microbial cells programmed to perform targeted therapeutic functionalities. His scientific contributions have been recognized with international honours and awards, including the Scientific and Technological Achievement Award from U.S. Environmental Protection Agency, and featured in leading media outlets worldwide. He serves as an editor and an editorial board member for a number of journals including Cell Systems, Metabolic Engineering, Biotechnology for Biofuels, ACS Synthetic Biology, and Critical Reviews in Microbiology. He serves on the advisory committee of key international research programs such as the Synthetic Biology Open Language (SBOL) and CSIRO Future Science Platform.

Section I: Advancing understanding of microbiome

Chapter 1: Systems biology and microbiome
Chapter 2: Synthetic biology and microbiome
Chapter 3: Computational modelling of microbiome and host-microbiome interactions
Chapter 4: Machine learning of the microbiome big data

Section II: Microbiome engineering

Chapter 5: Human microbiome engineering against pathogen infections
Chapter 6: Human microbiome engineering against cancer
Chapter 7: Human microbiome engineering against diabetes
Chapter 8: Human microbiome engineering against obesity
Chapter 9: Human microbiome engineering against mental disorders
Chapter 10: Human microbiome engineering against autoimmune and inflammatory disorders
Chapter 11: Husbandry microbiome engineering
Chapter 12: Plant-soil microbiome engineering
Chapter 13: Food microbiome engineering
Chapter 14: Beverage microbiome engineering

Section III: Perspectives on microbiome engineering

Chapter 15: Future perspectives on Microbiome and its applications