Oxidative Stress

Dr. Harold I. Zeliger holds a PhD in organic chemistry and has been a professor of chemistry and environmental science. He is a Certified Professional Chemist, a Board- Certified Forensic Examiner, and an EPA Certified Laboratory Director. Dr. Zeliger is the author of 51 technical publications, including basic research journal articles and patents. In his more than 40 years in the Chemical Process Industry, he has personally developed many industrial and consumer chemical products, designed chemical product warning labels and written Material Safety Data Sheets for toxic and flammable chemicals. Dr. Zeliger has investigated hundreds of toxic chemical exposures, environmental spills and discharges, chemical fires and explosions nationally and internationally. He has served repeatedly as an expert witness for both plaintiffs and defendants in chemical product, process, toxic exposure, environmental, flammable, intellectual property and subrogation claims. Dr. Zeliger has provided services for numerous forensic examinations, technology transfer and due diligence investigations. Dr. Zeliger’s research is in the area of chemical toxicology. His published work includes papers on the toxic effects of chemical mixtures and chemical causes of cancer clusters and two editions of Human Toxicology of Chemical Mixtures, Second Edition.

I. Oxidative Stress and Disease 1. Oxidative stress causes 2. Historical perspective 3. Chemicals and chemical mixtures 4. Particles and fibers 5. Air pollution 6. Alcohol, tobacco and recreational drug use 7. Radiation 8. Chronic inflammation 9. Chronic Trauma 10. Dietary choices 11. Sleep deprivation 12. Hot and cold Environmental temperature extremes 13. Pre-existing disease 14. Pharmaceutical drugs 15. Chronic psychological stress 16. Genetic and epigenetic factors

II. Mechanism of Disease Onset 17. Disease hallmarks and biomarkers 18. Disease clusters 19. Disease co-morbidities 20. Free radical attack on DA 21. Free radical attack on proteins 22. Free radical attack on lipophilic cell membranes 23. Free radical stability factors 24. Free radical attack on mitochondria and energy production 25. Immune System role 26. Obesity-oxidative stress-disease triangle: Impact of obesity oxidative stress and disease 27. Acute versus chronic oxidative stress 28. Age and late onset disease 29. Total oxidative stress

III. Oxidative Stress Index and Its Applications 30. Oxidative stress index and its premise 31. Predicting likelihood of disease onset 32. Identifying primary causes of specific diseases 33. Oxidative Stress Index as a public health survey instrument 34. Adverse drug reaction prediction 35. Predicting severity of COVID-19 and other diseases 36. Oxidative Stress Index as a virtual diagnostic tool 37. Disease prevention 38. Future applications