Dissipation and Control in Microscopic Nonequilibrium Systems

Steven J. Large (Autor)

Buch | Hardcover

XVII, 236 Seiten

2021 | 1st ed. 2021
Springer International Publishing (Verlag)
978-3-030-85824-7 (ISBN)

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This thesis establishes a multifaceted extension of the deterministic control framework that has been a workhorse of nonequilibrium statistical mechanics, to stochastic, discrete, and autonomous control mechanisms. This facilitates the application of ideas from stochastic thermodynamics to the understanding of molecular machines in nanotechnology and in living things. It also gives a scale on which to evaluate the nonequilibrium energetic efficiency of molecular machines, guidelines for designing effective synthetic machines, and a perspective on the engineering principles that govern efficient microscopic energy transduction far from equilibrium. The thesis also documents the author's design, analysis, and interpretation of the first experimental demonstration of the utility of this generally applicable method for designing energetically-efficient control in biomolecules. Protocols designed using this framework systematically reduced dissipation, when compared to naive protocols, in DNA hairpins across a wide range of experimental unfolding speeds and between sequences with wildly different physical characteristics.

lt;p>Dr. Steven Large grew up in Victoria, Canada, and received his undergraduate honours degree in Nanoscience in 2015 from the University of Guelph in Ontario, Canada. He then completed his PhD in Physics at Simon Fraser University in Vancouver, Canada, defending his thesis in December 2020 under the supervision of Prof. David Sivak. Currently, Dr. Large works as a Data Scientist with Viewpoint Investment Partners, in Calgary, Alberta, using quantitative analysis methods and machine learning techniques to develop robust long-term financial investment strategies.

Chapter 1. Introduction.- Chapter 2. Theoretical background.- Chapter 3. DNA hairpins I: Calculating the generalized friction.- Chapter 4. DNA Hairpins II: reducing dissipation in nonequilibrium protocols.- Chapter 5. DNA Hairpins III: robustness, variability, and conclusions.- Chapter 6. Stochastic control in microscopic nonequilibrium systems.- Chapter 7. Optimal discrete control: minimizing dissipation in discretely driven systems.- Chapter 8. On dissipation bounds: discrete stochastic control of nonequilibrium systems.- Chapter 9. Free energy transduction within autonomous systems.- Chapter 10. Hidden excess power and autonomous Maxwell demons in strongly coupled nonequilibrium systems.- Chapter 11. Conclusions and outlook.

Erscheinungsdatum	26.10.2021
Reihe/Serie	Springer Theses
Zusatzinfo	XVII, 236 p. 49 illus., 42 illus. in color.
Verlagsort	Cham
Sprache	englisch
Maße	155 x 235 mm
Gewicht	541 g
Themenwelt	Naturwissenschaften ► Physik / Astronomie ► Thermodynamik
Schlagworte	Biological systems in vivo • Deterministic control system • DNA hairpin • Irreversible Thermodynamics • Maxwell's demon • Maxwell’s Demon • molecular machine • Stochastic control mechanism • Stochastic Thermodynamics
ISBN-10	3-030-85824-3 / 3030858243
ISBN-13	978-3-030-85824-7 / 9783030858247
Zustand	Neuware