Pancreatic B Cell Biology in Health and Disease

Izortze Santin is assistant professor and researcher in the Department of Biochemistry and Molecular Biology of the University of the Basque Country (Leioa, Spain). She obtained her PhD in Genetics of autoimmune diseases in 2004, and then, she moved to the ULB Center for Diabetes Research (Brussels, Belgium) where she completed her formation in diabetes with functional studies in in vitro models of pancreatic beta cell and in vivo models of type 1 diabetes. Izortze Santin is best known for major experimental and conceptual contributions to the research of pancreatic beta cell dysfunction in type 1 diabetes. Indeed, her work has highlighted the implication of type 1 diabetes candidate genes in the regulation of several pathways related to pancreatic beta cell inflammation and death. Currently her main research line aims to characterize how T1D genes (coding and non-coding) and viral infections interact to trigger the autoimmune destruction of pancreatic beta cells in type 1 diabetes. To this aim, she has several ongoing funded projects related to type 1 diabetes pathogenesis, in which the study of pancreatic beta cell acquired a central role. Lorenzo Galluzzi is Assistant Professor of Cell Biology in Radiation Oncology at the Department of Radiation Oncology of the Weill Cornell Medical College, Honorary Assistant Professor Adjunct with the Department of Dermatology of the Yale School of Medicine, Honorary Associate Professor with the Faculty of Medicine of the University of Paris, and Faculty Member with the Graduate School of Biomedical Sciences and Biotechnology of the University of Ferrara, the Graduate School of Pharmacological Sciences of the University of Padova, and the Graduate School of Network Oncology and Precision Medicine of the University of Rome “La Sapienza”. Moreover, he is Associate Director of the European Academy for Tumor Immunology and Founding Member of the European Research Institute for Integrated Cellular Pathology. Galluzzi is best known for major experimental and conceptual contributions to the fields of cell death, autophagy, tumor metabolism and tumor immunology. He has published over 450 articles in international peer-reviewed journals and is the Editor-in-Chief of four journals: OncoImmunology (which he co-founded in 2011), International Review of Cell and Molecular Biology, Methods in Cell biology, and Molecular and Cellular Oncology (which he co-founded in 2013). Additionally, he serves as Founding Editor for Microbial Cell and Cell Stress, and Associate Editor for Cell Death and Disease, Pharmacological Research and iScience.

1. Pancreatic Beta Cell Dysfunction in Type 1 Diabetes: The Role of Ifn Laura Marroquí 2. Sexual Hormones and Diabetes: The Impact in Pancreatic Beta Cell Marta Garcia-Arévalo 3. Pancreatic Beta Cell Dysfunction in Monogenic Diabetes Mariana Igoillo-Esteve 4. The Role of Mirnas In Beta Cell Function Flora Brozzi 5. Pancreatic Beta Cell: How Environmental Endocrine Disruptors Alter Its Function Sergio Soriano 6. Enteroviral Infections and Pancreatic Beta Cell Dysfunction Anne Op De Beek 7. Long Non-Coding Rna-Regulated Pathways in Pancreatic Beta Cell: Their Role in Diabetes Izortze Santin 8. Pancreatic Beta Cell Biology in Health and Disease Cesar Martín