Liver and Ageing

Session 1 - Drug Metabolism 1 (Modifications in Rodent Livers). Possible mechanisms for aging-associated feminization of drug metabolizing ability of male rat liver. The age-related alterations in liver microsomal membranes: The effects of lipid peroxidation and dietary restriction. Session 2 - Drug Metabolism 2 (Rodents vs. Primates). Intrinsic age or gender-related alterations in human hepatic microsomal monooxygenases: Fact of fiction? The influence of frailty liver blood flow and size upon hepatic oxidation and conjugation in aged man. Session 3 - Phase II Reactions and Drug Toxicity. Age-related differences in the susceptibility to drug-induced hepatotoxicity. Different responses of subunit concentrations and enzyme activities of glutathione S-transferases (GSTs) to protein-free diet (PFD) between young and old rodent livers. Session 4 - Age Pigments and Protein Turnover. Ceroid and lipofuscin in the liver. History and its state of the art. Leupeptin causes an accumulation of lipofuscin-like substances and ubiquitin immunoreactivity in liver cells of young rats; A possible model for hepatocellular aging. T-Kininogen gene expression: Induction during aging and age-related changes during the acute phase response. Effect of age and dietary restriction on accumulation of altered proteins and degradation of proteins in mouse. Session 5 - Bile and Bile Salts. Bile acids and aging in relation to hypercholesterolemia in rats. Effect of dietary restriction on bile formation and liver plasma mebrane function and fluidity in aging female rats. Session 6 - Protein Synthesis and Acute Phase Response. The effect of age on the synthesis of rat liver proteins. The age-related decline in the induction of a heat shock protein is reversed by life-long dietary restriction. Studies on the expression of heat shock proteins as a function of age. Acute phase proteins in the elderly: Possible pharmacokinetic and dynamic implications. Session 7 - Enzyme Induction and Alterations. The effect of age on the induction of drug metabolising enzymes. Age related alteration and modulation of cytosolic enzymes of liver of rats. Session 8 - Endotoxin and EGF. The role of biological response modifiers in the diminished homeostatic control of old rats after endotoxin administration. Decreased liver DNA synthesis in old rats following partial hepatectomy is restored by epidermal growth factor. Session 9 - Membranes and Membrane Proteins. Influence of age on plasma low density lipoprotein metabolism in man. Age-induced restricted mobility of proteins in hepatocyte surface membranes: A possible determinant of membrane transport function. Session 10 - Mechanisms of Aging. A review on the recent advances in the membrane hypothesis of aging. Liver cytochrome P-450 detoxification system: Possible role in human aging and longevity. Role of interorgan metabolism and transport of glutathione in the regulation of circulatory status. Index of authors.