Dancing Protein Clouds: Intrinsically Disordered Proteins in Health and Disease, Part B

Prof. Vladimir N. Uversky, PhD, DSc, FRSB, FRSC, F.A.I.M.B.E., Professor at the Department of Molecular Medicine, Morsani College of Medicine, University of South Florida (USF), is a pioneer in the field of protein intrinsic disorder. He has made a number of groundbreaking contributions in the field of protein folding, misfolding, and intrinsic disorder. He obtained his academic degrees from Moscow Institute of Physics and Technology (Ph.D., in 1991) and from the Institute of Experimental and Theoretical Biophysics, Russian Academy of Sciences (D.Sc., in 1998). He spent his early career working mostly on protein folding at the Institute of Protein Research and the Institute for Biological Instrumentation (Russia). In 1998, moved to the University of California Santa Cruz. In 2004, joined the Indiana University-Purdue University Indianapolis as a Senior Research Professor. Since 2010, Professor Uversky is with USF, where he works on various aspects of protein intrinsic disorder phenomenon and on analysis of protein folding and misfolding processes. Prof. Uversky has authored over 1250 scientific publications and edited several books and book series on protein structure, function, folding, misfolding, and intrinsic disorder. He is also serving as an editor in a number of scientific journals. He was a co-founder of the Intrinsically Disordered Proteins Subgroup at the Biophysical Society and the Intrinsically Disordered Proteins Gordon Research Conference. Prof. Uversky collaborated with more than 12,500 colleagues from more than 2,750 research organizations in 89 countries/territories.

Preface Vladimir N. Uversky 1. Intrinsically disordered proteins of viruses: Involvement in the mechanism of cell regulation and pathogenesis Pushpendra Mani Mishra, Navneet C Verma, Chethana Rao, Vladimir N Uversky and Chayan K Nandi 2. Transient knots in intrinsically disordered proteins and neurodegeneration Marek Cieplak, Mateusz Chwastyk, Lukasz Mioduszewski and Belisa R. H. de Aquino 3. IDPs and their complexes in GPCR and nuclear receptor signaling Myriam Guillien, Albane le Maire, Assia Mouhand, Pau Bernadó, William Bourguet, Jean-Louis Banères and Nathalie Sibille 4. Intrinsic disorder-based design of stable globular proteins Galina S. Nagibina, Tatiana N. Melnik, Ksenia A. Glukhova, Vladimir N. Uversky and Bogdan S. Melnik 5. The pathophysiology of neurodegenerative disease: Disturbing the balance between phase separation and irreversible aggregation Chelsea J. Webber, Shuwen (Eric) Lei and Benjamin Wolozin 6. Context-dependent HOX transcription factor function in health and disease  Sarah E. Bondos, Gabriela Geraldo Mendes and Amanda Jons 7. Dancing while self-eating: Protein intrinsic disorder in autophagy Hana Popelka 8. Intrinsic disorder in the nickel-dependent urease network Barbara Zambelli, Luca Mazzei and Stefano Ciurli 9. Disorder and cysteines in proteins: A design for orchestration of conformational see-saw and modulatory functions Anukool A. Bhopatkar, Vladimir N. Uversky and Vijayaraghavan Rangachari