Early Life Origins of Ageing and Longevity

Alexander Vaiserman was born in Kyiv, Ukraine, in 1957. His research interests comprise epigenetics, epidemiology and experimental gerontology. He earned his MSc Degree in cytology and developmental biology from Kyiv State University in 1984, and his DSc degrees in normal physiology from Instiute of Gerontology (Kyiv, Ukraine) in 1991 and 2004, respectively. Since 1978, he has had a permanent position in the Instiute of Gerontology (Kyiv, Ukraine). Since 2010 to present hi is the head of the Laboratory of Epigenetics in the Instiute of Gerontology (Kyiv, Ukraine). He is the member of the Editorial Boards of the journals Biogerontology, Frontiers in Genetics of Aging, Journal of Genomic Medicine and Pharmacogenomics, and Journal of Gerontology & Geriatric Research.

SECTION I  OVERVIEW.- Introductory chapter.- SECTION II EXPERIMENTAL STUDY OF DOHAD.- Early Life Programming of Aging in Genetically Long-Lived Mice.- Immunological Basis of In Utero Programming of Adult Disease.- Developmental Programming of the GH/IGF Axis and Long Term Health.- Programming of Stress Responses.- Early-life Nutritional Programming of Adult Health Status.- Effects of In-Utero Conditions on Adult Feeding Preferences.- IUGR-Related Programming of Metabolic Syndrome and Type 2 Diabetes.- Early-life Programming of Osteoporosis.- Developmental Epigenetic Programming of Skeletal Muscle Aging.- Effect of fetal and child health on kidney development and long-term risk of hypertension and kidney disease..- Developmental Programming of Neuroimmune Function.- Epigenetics and neurodegeneration: role of early-life nutrition.- SECTION III  EPIDEMIOLOGICAL EVIDENCE.- Prenatal Undernutrition and Ageing and Longevity.- Influence of Maternal Obesity on the Long-Term Healthof Offspring.- Early Life Predictors of Women's Health and Ageing.- Early-Life Predictors of Exceptional Longevity.- Prenatal Undernutrition and Effects on Physical and Mental Health.-  Ancestral and early origins of adult mortality - a multigenerational approach.- SECTION IV  PERSPECTIVES AND IMPLICATIONS.- Social Policy and Public Health Perspectives of DOHaD: Implications for Policy Advocacy, Cross-Sectorial Collaboration and Health Promotion.- Index.

"This book is not only concerned with ageing but more generally with adult health. This is an important topic and there are now many studies showing that improving health, particularly at old age, requires looking into what happened since the conception and even to what happened to the parents. ... this book is particularly helpful for biogerontologists, but also for nutritionists and other physicians." (Éric Le Bourg, Biogerontology, September 09, 2019)