Hepatitis B Virus: Molecular Mechanisms In Disease And Novel Strategies For Therapy

Part 1 Molecular biology of hepatitus B virus: replication of HBV, C. Seeger; HBV gene expression, A. Siddiqui; animal models and experimental systems for the study of hepadnaviruses, W.H. Gerlich. Part 2 Infection and chronic diseases: natural course of HBV infection, H. Blum; genetic variants of HBV and their implications in disease, T. Harrison; the immunology of chronic hepatitis B, B. Rehemann and F. Chisari. Part 3 Hepatocellular carcinoma: HBV DNA integrationa and insertional mutagenesis, K. Koike; HBV transactivation and signal transduction, W.H. Caselmann and R. Koshy; oncogenes, tumour suppressors, and co-factors in hepatocellular carcinoma, M.A. Buendia. Part 4 Rational approaches for the prevention of infection and therapy: novel vaccines, F. Schoedel; cytokines and therapy, H. Thomas; the development of targetable vectors for the liver and prospects for gene therapy, L. Weiss and P-H Hofschneider.