Intrinsically Disordered Proteins
Academic Press Inc (Verlag)
978-0-12-816348-1 (ISBN)
Intrinsically Disordered Proteins provides students and researchers in biochemistry, molecular biology, and applied microbiology with a comprehensive and updated discussion of the complex dynamics of IDPs and IDRs.
Dr. Nicola Salvi is a research scientist at the Institut de Biologie Structurale in Grenoble, France. After receiving his doctorate from the Ecole Polytechnique Fédérale de Lausanne, Switzerland, under the supervision of Geoffrey Bodenhausen, he held a postdoctoral appointment at Harvard Medical School. Dr. Salvi is an expert in characterizing protein dynamics using nuclear magnetic resonance spectroscopy. He developed hybrid approaches in which spectroscopic evidence on intrinsically disordered proteins (IDPs) is combined with molecular dynamics simulation to obtain insights into the functional dynamics of IDPs. Dr. Salvi’s studies led to identifying mechanistic paradigms of IDP motions, with important implications for our understanding of their function.
1. Introduction to intrinsically disordered proteins and regions
PART I - Methodology 2. Ensemble descriptions of IDPs and IDRs: Integrating simulation and experiment 3. Experimental characterization of the dynamics of IDPs and IDRs by NMR 4. Single-molecule fluorescence studies of IDPs and IDRs
PART II - Molecular Mechanism 5. Experimental studies of binding of intrinsically disordered proteins to their partners 6. Modeling protein-protein interactions with intrinsically disordered proteins
PART III - Biology and Medicine 7. IDPs and IDRs in biomolecular condensates 8. Molecular mechanisms of fibrillation of IDPs 9. Perspectives on drug discovery strategies based on IDPs 10. Conclusion and future directions
Erscheinungsdatum | 21.06.2019 |
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Verlagsort | San Diego |
Sprache | englisch |
Maße | 191 x 235 mm |
Gewicht | 750 g |
Themenwelt | Naturwissenschaften ► Biologie ► Biochemie |
Naturwissenschaften ► Physik / Astronomie ► Angewandte Physik | |
ISBN-10 | 0-12-816348-8 / 0128163488 |
ISBN-13 | 978-0-12-816348-1 / 9780128163481 |
Zustand | Neuware |
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