Green Synthetic Processes and Procedures

Roberto Ballini is a Full Professor of Organic Chemistry at the Faculty of Sciences of the University of Camerino. The research interest of Prof. Ballini is mainly dedicated to Organic Synthesis, with particular attention to the field of eco-friendly processes (Green Chemistry). The growth and the survival of the chemical industry is the industrialised countries are connected with the possibility to develop synthetic processes able to combine high yields and selectivity with the use of eco-compatible reagents, catalysts and solvents and waste minimization. To reach the goal of environmental protection, the right approach is to focus attention on primary prevention (minimizing or avoiding waste formation) rather than on secondary remediation (mainly consisting in waste treatment). In this context our group has developed a variety of collaborations with other Universities (Rome, Bologna, Venezia, Urbino, Parma, Perugia, Chieti, Texas-USA, Badajoz-Spain, Siviglia-Spain, Nijmegen-Netherland, etc.). Of particular interest is the Chemistry of aliphatic nitro compounds, employed for new generations of carbon-carbon single bond and carbon-carbon double bond, for the cleavage of the carbon-carbon bond, and for their use as the key building blocks in the synthesis of important targets such as natural products featuring enhanced biologically activity. Other special fields of extensive interest also concern: (i)

Sustainability of Green Synthetic Processes and Procedures;

One-pot Organic Reactions;

Application of Step, Cumulative, and Global E-factor and Process Mass Intensity Metrics to Gauge Synthesis Efficiency: l-DOPA and Apixaban Pharmaceutical Examples;Flow Chemistry in Drug Discovery;

Sustainable Batch or Continuous-flow Preparation of Biomass-derived Fuels Using Sulfonated Organic Polymers;

Renewable Starting Materials, Biocatalysis, and Multicomponent Reactions: A Powerful Trio for the Green Synthesis of Highly Valued Chemicals;

Green Synthetic Procedures under Hydrodynamic and Acoustic Cavitation;

Mechanochemical Synthesis of Biologically Relevant Heterocycles;

New and Up-and-coming Perspectives for Unconventional Chemistry: From Molecular Synthesis to Hybrid Materials by Mechanochemistry;

Microwave Dielectric Heating for Solvent-free Organic Transformations;

Advances in Catalysis for More Sustainable Synthesis of Phenolics;

Transition Metal Catalysis in Micellar Media: Much More Than a Simple Green Chemistry Promise;

Supported ILs and Materials Based on ILs for the Development of Green Synthetic Processes and Procedures;

CO2 and Organic Carbonates for the Sustainable Valorization of Renewable Compounds;

Transition Metal-catalysed Nucleophilic Additions of Terminal Alkynes in Water: Development and Synthetic Utility