Mass Spectrometry

Professor James McCullagh is a lecturer in Analytical Chemistry at the University of Oxford and Director of the Mass Spectrometry Research Facility in the Department of Chemistry. He spent several years in industry before moving to academia where he now conducts research developing novel mass spectrometry and separation science techniques and applies these at the interfaces between chemistry, biology and medicine. In his early career he used mass spectrometry to investigate diet and nutrition and developed methods for compound-specific radiocarbon dating. In the last ten years his research has focussed on understanding the role of small molecules in health and disease and developing metabolomics and isotope tracer techniques. Current interests focus on measuring central energy metabolism and understanding its perturbations in diseases including diabetes and cancer. He is the author of over 80 research papers and books. Professor Neil Oldham is Professor of Biomolecular Mass Spectrometry in the School of Chemistry at the University of Nottingham. His research activities are focussed on the use of mass spectrometry and associated techniques for the study of protein structure, interactions and modification, although he also has considerable experience in small molecule mass spectrometry and natural product analysis. He has authored over 130 research papers in the field of applied mass spectrometry. His teaching interests span organic and biological chemistry, organic spectroscopy and analytical chemistry.

1: Introduction 2: Methods of ionization 3: Methods of mass analysis 4: Resolution, accurate mass and sensitivity 5: Tandem mass spectrometry 6: Interpretation of mass spectra 7: Separation techniques and quantification 8: Mass spectrometry applications