Molecular Mechanisms of Dementia

Akhlaq A. Farooqui is a leader in the field of signal transduction processes, lipid mediators, phospholipases, glutamate neurotoxicity, and neurological disorders. He is a research scientist in the Department of Molecular and Cellular Biochemistry at The Ohio State University. He has published cutting edge research on the role of phospholipases A2 in signal transduction processes, generation and identification of lipid mediators during neurodegeneration by lipidomics. He has studied the involvement of glycerophospholipid, sphingolipid-, and cholesterol-derived lipid mediators in kainic acid neurotoxicity, an experimental model of neurodegenerative diseases. Akhlaq A. Farooqui has discovered the stimulation of plasmalogen- selective phospholipase A2 in brains of patients with Alzheimer disease (AD). Stimulation of this enzyme may not only be responsible for the deficiency of plasmalogens in neural membranes of AD patients, but also be related to the loss of synapse in the AD.

1. Neurochemical Aspects of Dementia2. Neurochemical aspects of post-stroke dementia3. Neurochemical Aspects of Alzheimer’s Type of Dementia4. Neurochemical aspects of Lewy body dementia5. Neurochemical aspects of vascular dementia6. Neurochemical aspects of frontotemporal dementia7. Potential treatment strategies for dementia with pharmacological and non-pharmacological interventions8. Potential treatment strategies for the treatment of dementia with Chinese medicinal plants9. Potential treatment strategies of dementia with Ayurvedic medicines10. Summary and perspective for future research on dementia