Optimum Overall Treatment Time in Radiation Oncology

Optimum Overall Treatment Time in Radiation Oncology
Chapter 1: The Origins of Linear Quadratics
1.1 A 60+ Year Quest to Find How Fractionation Really Works, 1950 - 2014
1.2 The Linear Quadratic Concept and its Relevance to Clinically Sized Doses
in Radiotherapy
1.3 Time to Think
Chapter 2: LQ Modeling
2.1 The Simplest Modeling
2.2 The Seven Steps to Linear Quadratic Heaven: A Brief Summary
2.3 The Details
Chapter 3: Dose and Effectiveness
3.1 Biologically Effective Dose
3.2 Relative Effectiveness (RE)
3.3 Overall Treatment Time and Tolerances
3.3.1 Late Normal Tissue Complications
3.3.2 Acute Mucosal Tolerance
Chapter 4: Normalized Total Dose
4.1 Converting from BED to NTD or EQD
4.2 Gamma Slopes, the Standard of Prescription of Estimates of BED or NTD
4.3 How to Evaluate a New Schedule - a Summary
Chapter 5: A Review of Schedules
5.1 Some of the Best-known Schedules
5.2 Standard Fractionation
5.3 Hyperfractionation
5.4 RTOG 90-03
5.5 Initially Too Hot in Table 5 - 1
5.6 General Considerations
5.7 The Danish Six Fractions a Week
5.8 Appropriateness of LQ Modeling
Chapter 6: How to Obtain Curves with Peaks of Optimum Overall Treatment Times
6.1 Differences Between 7 Days and 3 - 4 Weeks in Tk
6.2 The Problem of Finding an Optimum Overall Time
Chapter 7: Time and Repopulation
7.1 Results vs Days of Overall Time
7.1.1 Two Fractions a Day Give More Tumor Log Cell Kill than One Fraction a Day
7.1.2 The Effect of Assuming Faster or Slower Repopulating Rates
7.2 Discussion: The Exceptional Cases of Very Fast Repopulation
Chapter 8: Should We Ever Use One Fraction a Day?
8.1 Discussion: Is One Fraction a Day Still to Be Used?
8.2 Main Conclusions
8.2.1 Conclusion #1: 2F/Day is Nearly Always Better than 1F/Day
8.2.2 Conclusion #2: Investigate Repopulation Rates for Use in Longer Schedules
8.3 Discussion: Smaller and Smaller Fractions
8.4 Discussion: How Long Is Really Too Long?
Chapter 9: How Short is Too Short?
9.1 Introduction
9.2 Acute Tolerance Calculations Are Also Worth Doing
Chapter 10: Recovery
10.1 Incomplete Recovery
10.2 Incomplete Recovery as a Loss of Effect in Prolonged Fractions
Chapter 11: The Influence of Inter-patient Heterogeneity
11.1 Introduction
11.2 Tumor Control Probability Modeling
11.3 Results and Discussion
11.4 Summary
Chapter 12: Final Thoughts
Photographs
Glossary
References and Additional Resources