Chemical Biology

Identification of Therapeutic Small Molecule Leads in Cultured Cells Using Multiplexed Pathway Reporter Read-outs.- Applying the Logic of Genetic Interaction to Discover Small Molecules That Functionally Interact with Human Disease Alleles.- Construction and Application of a Photo-cross-linked Chemical Array.- High Content Screening for Modulators of Cardiac Differentiation in Human Pluripotent Stem Cells.- Small Molecule High-Throughput Screening Utilizing Xenopus Egg Extract.- Fission Yeast-based High-throughput Screens for PKA Pathway Inhibitors and Activators.- A Method for High-throughput Analysis of Chronological Aging in Schizosaccharomyces pombe.- Protocols for the Routine Screening of Drug Sensitivity in the Human Parasite Trichomonas vaginalis.- Chemical Genetic Screens Using Arabidopsis thaliana Seedlings Grown on Solid Medium.- Small Molecule Screening Using Drosophila Models of Human Neurological Disorders.- High-throughput Small Molecule Screening in Caenorhabditis elegans.- Whole-organism Screening for Modulators of Fasting Metabolism Using Transgenic Zebrafish.- High Content Screening for Modulators of Cardiovascular or Global Developmental Pathways in Zebrafish.- Extraction Methods of Natural Products from Traditional Chinese Medicines.- Bioassay-guided Identification of Bioactive Molecules from Traditional Chinese Medicines.- NMR Screening in Fragment-Based Drug Design: A Practical Guide.- Practical Strategies for Small Molecule Probe Development in Chemical Biology.- Principal Component Analysis as a Tool for Library Design: A Case Study Investigating Natural Products, Brand-name Drugs, Natural Product-like Libraries, and Drug-like Libraries.- Small Molecule Library Screening by Docking with PyRx.- Fluorous Photoaffinity Labeling to Probe Protein-Small Molecule Interactions.- Identification of the Targets of Biologically Active Small Molecules Using Quantitative Proteomics.- Drug Affinity Responsive Target Stability (DARTS) for Small Molecule Target Identification.- Chemical Genomic Profiling via Barcode Sequencing to Predict Compound Mode of Action.- Image-Based Prediction of Drug Target in Yeast.