Genome Editing (eBook)

Kursad Turksen received his Ph.D. from the University of Toronto in Toronto, Canada in the area of osteoprogenitor biology and cell selection methodologies. He completed his postdoctoral training at the Howard Hughes Medical Institute, University of Chicago, in Chicago, Illinois, studying epidermal biology through use of genetically-altered mouse models. He joined the Ottawa Hospital Research Institute in Ottawa, Canada [previously known as the Loeb Research Institute] where he rose to the position of Senior Scientist in the Division of Regenerative Medicine. His research interests focus on stem cell biology, with a particular interest in the Claudin family of tight junction proteins and their role in epidermal lineage commitment and progression during development in health and disease. Dr. Turksen is currently Editor in Chief of the Springer journal Stem Cell Reviews and Reports in addition to serving as series editor for the Springer series Stem Cell Biology and Regenerative Medicine.

Genome Editing with Targetable Nucleases.- CRISPR/Cas9 Approaches to Investigate the Non-coding Genome.- At the Conflux of Human Genome Engineering and Induced Pluripotency.- CRISPR/Cas9 and the Paradigm Shift in Mouse Genome Manipulation Technologies.- Genome Editing Technology in CRISPR/Cas System: How to Increase Knock-in Efficiency in Mouse Zygotes.- Developments in the Generation of Reporter Stem Cells.- Current Status of Genome Editing in Cardiovascular Medicine.- Using CRISPR-Cas9 Genome Editing to Enhance Cell Based Therapies for the Treatment of Diabetes Mellitus.- Genome Editing in the Retina: a Case Study in CRISPR for a Patient-Specific Autosomal Dominant Retinitis Pigmentosa Model.- Index.