Fifty Years of Cytochrome P450 Research

Preface.- Part 1 Cytochrome P450 History.- 1 Pioneers in the Early Years of Cytochrome P450 Research.- 2 Fifty Years of Progress in Drug Metabolism and Toxicology: What Do We Still Need to Know About Cytochrome P450 Enzymes?.- 3 Fifty Years of Cytochrome P450 Research: Examples of What We Know and Don’t Know.- Part 2 Structure, Function, and Practical Applications of P450.- 4 Cytochrome P450 Dynamics.- 5 Structural and Functional Diversity of Cytochrome P450.- 6 Oxygenation of Non native Substrates Using a Malfunction State of Cytochrome P450s.- 7 Plant Cytochrome P450s in Triterpenoid Biosynthesis: Diversity and Application to Combinatorial Biosynthesis.- 8 Mammalian and Bacterial Cytochromes P450 Involved in Steroid Hydroxylation: Regulation of Catalysis and Selectivity and Potential Applications.- 9 Neurosteroids: Regional Steroidogenesis.- 10 Whole Cell-Dependent Biosynthesis of Drug Metabolites Using Genetically Engineered Budding Yeast.- 11 Metabolic Diversity and Cytochromes P450 of Fungi.- 12 Metabolic Engineering of Flower Colour Pathways Using Cytochromes P450.- Part 3 Gene Regulation of P450.- 13 Aryl Hydrocarbon Receptor Suppresses Cecal Carcinogenesis.- 14 Epidermal Growth Factor Receptor: The Phenobarbital Receptor That Elicits CAR Activation Signal for P450 Induction.- 15 Steroidogenic Cytochrome P450 Gene CYP11A1: Functions and Regulation.- 16 Cooperative Regulation of Expression of Cytochrome P450 Enzymes by Aryl Hydrocarbon Receptor and Vitamin D Receptor.- Part 4 Drug Metabolism.- 17 Species, Ethnic and Individual Differences in Human Drug-Metabolizing Cytochrome P450 Enzymes.- 18 Cytochrome P450-Depedent Change in UDP- Glucuronosyltransferase Function and Its Reverse Regulation.- 19 Control of Xeno/Endobiotics-Metabolizing Cytochrome P450s by Micro RNAs.- 20 The Pharmacogenomics of Cytochrome P450s: From Molecular to Clinical Application.- 21 Cytochrome P450 Polymorphisms of Clinical Importance.- BM Epilogue.- Index.