Structural Virology (eBook)

eBook Download: PDF
2010
388 Seiten
Royal Society of Chemistry (Verlag)
978-1-84973-223-9 (ISBN)

Lese- und Medienproben

Structural Virology -
Systemvoraussetzungen
179,99 inkl. MwSt
  • Download sofort lieferbar
  • Zahlungsarten anzeigen
This exceptional monograph, by experts in structural biology and virology, is for biomedical scientists involved in basic and applied research.
Over the last ten years, much effort has been devoted to improving the biophysical techniques used in the study of viruses. This has resulted in the visualization of these large macromolecular assemblages at atomic level, thus providing the platform for functional interpretation and therapeutic design. Structural Virology covers a wide range of topics and is split into three sections. The first discusses the vast biophysical methodologies used in structural virology, including sample production and purification, confocal microscopy, mass spectrometry, negative-stain and cryo-electron microscopy, X-ray crystallography and nuclear magnetic resonance spectroscopy. The second discusses the role of virus capsid protein structures in determining the functional roles required for receptor recognition, cellular entry, capsid assembly, genome packaging and mechanisms of host immune system evasion. The last section discusses therapeutic strategies based on virus protein structures, including the design of antiviral drugs and the development of viral capsids as vehicles for foreign gene delivery. Each topic covered will begin with a review of the current literature followed by a more detailed discussion of experimental procedures, a step in the viral life cycle, or strategies for therapeutic development. With contributions from experts in the field of structural biology and virology this exceptional monograph will appeal to biomedical scientists involved in basic and /or applied research on viruses. It also provides up-to-date reference material for students entering the field of structural virology as well as scientists already familiar with the area.

Mavis Agbandje-McKenna is currently Director of the Center for Structural Biology and Associate Professor at the University of Florida College of Medicine. She obtained her BSc (Hons) in Human Biology and Chemistry from the University of Hertfordshire and a PhD in Biophysics at the University of London Institute of Cancer Research. Her postdoctoral research was at Purdue University before she was appointed Senior Research Fellow at the University of Warwick, UK. Robert McKenna obtained his BSc (Physics and Biology) and PhD in Crystallography from the University of London. His postdoctoral research was at Purdue University before he accepted the post of Warwick Research Fellow in the Department of Biological Sciences at the University of Warwick. He is currently Associate Professor at the University of Florida College of Medicine.

Introduction: Principles of Virus Structure Section 1Methodologies for Structural Analysis of Viruses Production and Purification of Viruses for Structural Studies Microscopic (Confocal) Analysis of Viral Entry and Infection Cryo-electron Microscopy of Virus Infection - Tomography and Asymmetric Structure Determination Cryo-electron Microscopy of Viruses - 3D of Virus Capsids X-ray Crystallography of Virus Capsids Structural Studies of Viral Proteins Probing Viral Capsid Structures in Solution Section 2Structure to Function Correlation for Viruses Evolution of Viral Capsid Structures - the Three Domains of Life Mechanisms of Virus Capsid Assembly Mechanisms of Genome Packaging Attachment and Viral entry - Receptor Recognition in Viral Pathogenesis Attachment and Entry - Viral Cell Fusion Virus Antibody Recognition Section 3Therapeutic Strategies Based on Viral Structures Development of anti-HIV drugs Design of Influenza Vaccines and Antiviral Agents Engineering Viral Capsids as Nano Tools Viral Vectors for Gene Delivery

Erscheint lt. Verlag 11.11.2010
Reihe/Serie ISSN
ISSN
Verlagsort Cambridge
Sprache englisch
Themenwelt Medizin / Pharmazie Gesundheitsfachberufe
Medizin / Pharmazie Medizinische Fachgebiete Mikrobiologie / Infektologie / Reisemedizin
Naturwissenschaften Biologie Genetik / Molekularbiologie
Naturwissenschaften Biologie Mikrobiologie / Immunologie
Naturwissenschaften Chemie
Schlagworte Structural • Virology
ISBN-10 1-84973-223-X / 184973223X
ISBN-13 978-1-84973-223-9 / 9781849732239
Haben Sie eine Frage zum Produkt?
PDFPDF (Adobe DRM)

Kopierschutz: Adobe-DRM
Adobe-DRM ist ein Kopierschutz, der das eBook vor Mißbrauch schützen soll. Dabei wird das eBook bereits beim Download auf Ihre persönliche Adobe-ID autorisiert. Lesen können Sie das eBook dann nur auf den Geräten, welche ebenfalls auf Ihre Adobe-ID registriert sind.
Details zum Adobe-DRM

Dateiformat: PDF (Portable Document Format)
Mit einem festen Seiten­layout eignet sich die PDF besonders für Fach­bücher mit Spalten, Tabellen und Abbild­ungen. Eine PDF kann auf fast allen Geräten ange­zeigt werden, ist aber für kleine Displays (Smart­phone, eReader) nur einge­schränkt geeignet.

Systemvoraussetzungen:
PC/Mac: Mit einem PC oder Mac können Sie dieses eBook lesen. Sie benötigen eine Adobe-ID und die Software Adobe Digital Editions (kostenlos). Von der Benutzung der OverDrive Media Console raten wir Ihnen ab. Erfahrungsgemäß treten hier gehäuft Probleme mit dem Adobe DRM auf.
eReader: Dieses eBook kann mit (fast) allen eBook-Readern gelesen werden. Mit dem amazon-Kindle ist es aber nicht kompatibel.
Smartphone/Tablet: Egal ob Apple oder Android, dieses eBook können Sie lesen. Sie benötigen eine Adobe-ID sowie eine kostenlose App.
Geräteliste und zusätzliche Hinweise

Buying eBooks from abroad
For tax law reasons we can sell eBooks just within Germany and Switzerland. Regrettably we cannot fulfill eBook-orders from other countries.

Mehr entdecken
aus dem Bereich