Biomarker Discovery in the Developing World: Dissecting the Pipeline for Meeting the Challenges

Srivastava, Sanjeeva Associate Professor, Indian Institute of Technology Bombay, India. Proteomics is truly a global science with contributors from numerous countries and continents. Dr. Srivastava is an active contributor to global proteomics science and innovation. He serves on the Executive Committee of the Proteomics Society of India, and is a member of HUPO and US-HUPO. He contributes actively to the “HUPO Website and Social Media Committee” as a member and the Human Infectious Diseases HPP initiative as a coordinator. In HUPO conferences he has participated as invited speaker, session chair, and judge. In an effort to enhance proteomics education and awareness among the community and citizens, his group has recently developed a proteomics documentary, which portrays the proteomics journey from lab to “innovation-in-society”. As a Canadian trained in proteomics at Alberta and Harvard universities, he returned to India in 2009 and has established an innovative proteomics laboratory at the IITB. The research focus of Sanjeeva’s team centers on using high-throughput proteomics in brain tumors and infectious diseases with over 75 publications accomplished in a span of six years.He has organized two successful conferences – PSI-2014 and Targeted Proteomics International Symposium in 2015. He has published three special issues, “Proteomics in India” for Journal of Proteomics; “Proteomics Research in India” for Nature India, and “Protein Arrays” for Proteomics. Having extensive teaching experience at IITB and experience of conducting proteomics courses at CSHL provided him with the background to increase proteomics education for the global community. One of his special contributions has been the development of e-learning resources (MOOC, Virtual Proteomics Laboratory). Taken together, his series of research and teaching initiatives is contributing to and fully synchronized with the mission and current actives of HUPO. He continues to develop proteomics science and innovation together with and for the next generation of keen students, researchers, and the research and education commons in Asia and global HUPO community.

Chapter 1: Exigencies of biomarker research in developing world: A focus on the dearth of biobanking resources.- Chapter 2: Geographic pervasiveness of cancer: Prospects of novel biomarker and therapeutic research in developing countries using OMICs approaches.- Chapter 3: Omics data processing and analysis.- Chapter 4: Basics of mass spectrometry and its applications in biomarker discovery.- Chapter 5: Angel Philanthropy and Crowdfunding to Accelerate Cancer Research in Developing World.- Chapter 6: Delivering on the Promise of Bioeconomy in Developing World: Link it with Social Innovation and Education.- Chapter 7: Role of proteomics in characterization of biosimilar products.- Chapter 8: Regulatory norms and intellectual property rights for biomarker research.