Neuronal Tissue-Nonspecific Alkaline Phosphatase (TNAP) (eBook)

PART 1 Disease forms and animal models of hypophosphatasia1 Clinical forms and animal models of hypophosphatasia2 Molecular genetics of hypophosphatasia and phenotype-genotype correlations Etienne MORNET 3 Genetically modified mice for studying TNAP functionSonoko NARISAWAPART 2 Expression and regulation of TNAP in the CNS4 Tissue-Nonspecific Alkaline Phosphatase in the Developing Brain and in Adult NeurogenesisHerbert Zimmermann and David Langer5 Rediscovering TNAP in the brain: a major role in regulating the function and development of the cerebral cortexCaroline Fonta, Pascal Barone, Laia Rodriguez Martinez and László Négyessy6 TNAP in the retinaOrsolya Kántor, Dorottya Cserpán, Béla Völgyi, Ákos Lukáts, Zoltán Somogyvári7 Tissue Non-specific Alkaline Phosphatase (TNAP) in vessels of the brain Barbara Deracinois, Anne-Marie Lenfant, Marie-Pierre Dehouck  and Christophe FlahautPART 3 TNAP functions in the nervous system8 What can we learn about the neural functions of TNAP from studies on other organs and tissues? José Luis Millán9 TNAP, an essential player in membrane lipid rafts of neuronal cellsMyriam Ermonval, Florence Baychelier, Caroline Fonta10 Signal transduction pathways of TNAP: molecular network analysesNégyessy L, Györffy B, Hanics J, Bányai M, Ermonval M, Fonta C, Bazsó F 11 Vitamin B-6 Metabolism and Interactions with TNAPStephen P. Coburn12 Tetramisole and levamisole suppress neuronal activity independently from their inhibitory action on Tissue Non-Specific Alkaline Phosphatase in mouse cortex Lionel G. Nowak, Benoît Rosay, David Czégé, Caroline Fonta 13 TNAP and Pain ControlSarah E. Street and Nathaniel A. SowaPART 4 TNAP in neurological disorders14 Neurological symptoms of HypophosphatasiaTakeshi Taketani15 Recombinant enzyme replacement therapy in hypophosphatasiaHofmann C, Jakob F, Seefried L, Mentrup B, Graser S, Plotkin H, Girschick HJ, Liese J16 Neurogenetic Aspects of Hyperphosphatasia in Mabry SyndromeDavid E.C. Cole and Miles D. Thompson17 The role of tissue non-specific alkaline phosphatase (TNAP) in Neurodegenerative diseases: Alzheimer’s disease in the focusKatherine AB Kellett & Nigel M Hooper18 TNAP plays a key role in neural differentiation as well as in neurodegenerative disordersDiaz-Hernandez M, Hernandez F, Miras-Portugal M.T.  and Avila JIndex