Clinical Toxinology in Asia Pacific and Africa (eBook)

Clinical toxinologic conditions are becoming increasingly frequent, more so than is generally recognized. The conditions comprise of clinical aspects such as the diagnosis, management, and prevention of snakebite envenoming, scorpion sting, mushroom toxins, plant toxins, and other natural toxins. Clinical toxinology also deals with the ecology, epidemiology, regional differences, and varieties of fauna accounting for different envenoming manifestations.

 

This handbook includes 30 chapters addressing various topics on clinical toxinology such as the epidemiology and management of snakebites in different Asian and African countries, disability following snakebite, effect of snake venoms on hemostasis, socioeconomic  aspects of snakebites, therapeutic application of snake venom, scorpion sting in the Middle East, jellyfish sting, etc. These titles are written by experts currently working in the subspecialty, many of whom have first-hand experience in the relevant research fields. In virtually all the topics, appropriate illustrations are provided to simplify comprehension including tables, figures and pictures.

 

This reference work on Clinical Toxinology in Asia Pacific and Africa, in the Toxinology handbook series, is designed to keep readers abreast with new knowledge and experience in toxinology regionally and globally. Toxinologists, researchers, scientists, and experts in this field from various working areas considered it necessary to collect all the aspects of clinical toxinology in a single, handy handbook. This can be used by medical students, postgraduate students, general practitioners, specialists in internal medicine, critical care physicians, emergency physicians, and anesthetists worldwide.

Prof P. Gopalakrishnakone is a world leader in the characterization of the structure and function of animal and plant toxins and chemical poisons, which contain highly specific and biologically active components. He has contributed significantly to the body of knowledge regarding the anatomy of snake venom glands and the development of drug candidates from animal toxins. Prof Gopal pioneered the development of the NUS Venom and Toxin Research Programme, which has put NUS at the forefront of toxin research internationally. The technology platform that has been built over the years under the Venom and Toxin Research Programme, coupled with its extensive library of protein and peptides, has enabled Prof Gopal and his team to complete the discovery process of lead candidates in time and to transfer valuable supplementary information to the next discovery steps involving profiling and optimization of lead candidates. The objective is to characterize the venom components and natural toxins at a molecular level and identify promising compounds amenable to the development of novel human therapeutics. Prof Gopal's lab has identified over twenty peptides with unique medical indications from venom-based proteins with some already under development as therapeutics. His research studies includes structure function studies (toxin detection, biosensors, antitoxins and neutralization factors), toxicogenomics and expression studies, antimicrobial peptides from venoms and toxins and PLA2 inhibitors as potential drug candidate for inflammatory diseases. The techniques he employs include quantum dots to toxinology, computational biology, microarrays and protein chips. He has patented analgesic peptide, anti inflammatory peptide as well as anti rheumatoid arthritis peptides. He is exploring various possibilities of delivery systems for these peptides to target sites and administration of these peptides orally, transdermally, ocular and injections.Prof Gopal has over 100 international peer-reviewed papers in venom and toxin research, drug discovery, biosensors and toxinogenomics. His research awards include the Outstanding University Researcher Award from the National University of Singapore (1998); Ministerial Citation, NSTB Year 2000 Award in Singapore; and the Research Excellence Award from the Faculty of Medicine, National University of Singapore (2003). His awards in teaching include, Faculty Teaching Excellence Award 2003/4 & NUS Annual Teaching Excellence Award 2003/4. He also received the Faculty Teaching Excellence Award in 2009/10 and the Annual Teaching Excellence Award, NUS FOR 2009/10. He is the President of International Society on Toxinology till 2012 and is a member of the editorial board of Toxicon, the official journal of the International Society on Toxinology.

Abul Faiz, MBBS, FCPS, FRCP, PhD, a professor of medicine is a former administrative chief of the Dhaka Medical College, former Dean of the Faculty of Medicine of the University of Dhaka and was Director General of Health Services of the Govt. of Bangladesh. Professor Faiz is a member of the World Health Organization Malaria Treatment Guideline Committee, the National Steering Committee for the elimination of Kala Azar, Bangladesh, and Regional Technical Advisor for malaria, SEARO WHO. Currently he is the President, Bangladesh Association for Advancement of Tropical Medicine (BAATM), and Toxicology Society of Bangladesh (TSB). He is member of the Board of Drugs for the Neglected Diseases Initiative (DNDi); International Advisory Board, Davidson's Principles & Practice of Medicine; editorial board, Asian Neurology, and Journal of Bangladesh Society of Medicine. He has been involved as principal investigator in key clinical studies on malaria. He has the credit of publication of several hundred articles in peer reviewed journal.

Christeine Ariaranee Gnanathasan, MBBS, Mphil (Col), MD (Col), MRCP (UK), FRCP (Lond), is Professor in Medicine in the Department of Clinical Medicine, Faculty of Medicine, University of Colombo, Sri Lanka and Consultant Physician to the University Medical Unit, National Hospital of Sri Lanka, Colombo. Professor Gnanathasan is involved in teaching activities in the faculty as well as patient care in the University Medical Unit, National Hospital of Sri Lanka.

Abdulrazaq Garba Habib, MBBS, MSc Epid [Lond], MRCP (UK), FWACP, FAMS (Infect Dis), FRCP [Lond], CTH^(TH), is an infectious and tropical diseases physician and epidemiologist. He is the former Dean Faculty of Medicine and the current Provost of the College of Health Sciences, Bayero University Kano and Consultant in Infectious & Tropical Diseases at Aminu Kano Teaching Hospital Kano, Nigeria. He hails from Kano, Nigeria, and is happily married with children.

Ravindra  Fernando, MBBS, MD, FCCP, FCGP, FRCP(London), FRCP (Glasgow), FRCP (Edinburgh), FRCPath (UK) and DMJ (London), is the chair and senior professor of Forensic Medicine and Toxicology, University of Colombo, Sri Lanka.

Chen-Chang Yang, MD, MPH, DrPH, is currently an Associate Professor and the Chair of Environmental & Occupational Health Sciences at the School of Medicine, National Yang-Ming University, Taiwan. He is also an Attending Physician and the Director of the Division of Clinical Toxicology & Occupational Medicine at the Department of Medicine, Taipei Veterans General Hospital, Taiwan. Moreover, he is the Director of the National Poison Control Center in Taiwan.

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Clinical toxinologic conditions are becoming increasingly frequent, more so than is generally recognized. The conditions comprise of clinical aspects such as the diagnosis, management, and prevention of snakebite envenoming, scorpion sting, mushroom toxins, plant toxins, and other natural toxins. Clinical toxinology also deals with the ecology, epidemiology, regional differences, and varieties of fauna accounting for different envenoming manifestations. This handbook includes 30 chapters addressing various topics on clinical toxinology such as the epidemiology and management of snakebites in different Asian and African countries, disability following snakebite, effect of snake venoms on hemostasis, socioeconomic aspects of snakebites, therapeutic application of snake venom, scorpion sting in the Middle East, jellyfish sting, etc. These titles are written by experts currently working in the subspecialty, many of whom have first-hand experience in the relevant research fields. In virtually all the topics, appropriate illustrations are provided to simplify comprehension including tables, figures and pictures. This reference work on Clinical Toxinology in Asia Pacific and Africa, in the Toxinology handbook series, is designed to keep readers abreast with new knowledge and experience in toxinology regionally and globally. Toxinologists, researchers, scientists, and experts in this field from various working areas considered it necessary to collect all the aspects of clinical toxinology in a single, handy handbook. This can be used by medical students, postgraduate students, general practitioners, specialists in internal medicine, critical care physicians, emergency physicians, and anesthetists worldwide.