Biochemistry: A Short Course

John L. Tymoczko is Towsley Professor of Biology at Carleton College, where he has taught since 1976. He currently teaches Biochemistry, the Metabolic Basis of Human Disease, Oncogenes and the Molecular Biology of Cancer, and Exercise Biochemistry and co-teaches an introductory course, Energy Flow in Biological Systems. Jeremy M. Berg received his B.S. and M.S. degrees in Chemistry from Stanford (where he did research with Keith Hodgson and Lubert Stryer) and his Ph.D. in Chemistry from Harvard with Richard Holm. He then completed a postdoctoral fellowship with Carl Pabo in Biophysics at Johns Hopkins University School of Medicine. Lubert Stryer is Winzer Professor of Cell Biology, Emeritus, in the School of Medicine and Professor of Neurobiology, Emeritus, at Stanford University, where he has been on the faculty since 1976. He received his M.D. from Harvard Medical School.

PART I: THE MOLECULAR DESIGN OF LIFE Section 1. Biochemistry 1. Biochemistry and the Unity of Life 2. Water, Weak Bonds and the Generation of Order Out of Chaos Section 2. Protein Composition and Structure 3. Amino Acids 4. Protein Three-Dimensional Structure 5. Techniques in Protein Biochemistry Section 3. Basic Concepts and Kinetics of Enzymes 6. Basic Concepts of Enzyme Action 7. Kinetics and Regulation 8. Mechanisms and Inhibitors 9. Hemoglobin, An Allosteric Protein Section 4. Carbohydrates and Lipids 10. Carbohydrates 11. Lipids Section 5. Cell Membranes, Channels, Pumps and Receptors 12. Membrane Structure and Function 13. Signal-Transduction Pathways PART II: TRANSDUCING AND STORING ENERGY Section 6. Basic Concepts and Design of Metabolism 14. Digestion: Turning a Meal into Cellular Biochemicals 15. Metabolism: Basic Concepts and Design Section 7. Glycolysis and Gluconeogenesis 16. Glycolysis 17. Gluconeogenesis Section 8. The Citric Acid Cycle 18. Preparation for the cycle 19. Harvesting electrons from the cycle Section 9. Oxidative Phosphorylation 20. The Electron-Transport Chain 21. The Proton-Motive Force Section 10. The Light Reactions of Photosynthesis and the Calvin Cycle 22. The Light Reactions 23. The Calvin Cycle Section 11. Glycogen Metabolism and the Pentose Phosphate Pathway 24. Glycogen Degradation 25. Glycogen Synthesis 26. The Pentose Phosphate Pathway Section 12. Fatty Acid and Lipid Metabolism 27. Fatty Acid Degradation 28. Fatty Acid Synthesis 29. Lipid Synthesis: Storage Lipids, Phospholipids, and Cholesterol Section 13. The Metabolism of Nitrogen-Containing Molecules 30. Amino Acid Degradation and the Urea Cycle 31. Amino Acid Synthesis 32. Nucleotide Metabolism PART III: SYNTHESIZING THE MOLECULES OF LIFE Section 14. Nucleic Acid Structure and DNA Replication 33. The Structure of Informational Macromolecules: DNA and RNA 34. DNA Replication 35. DNA Repair and Recombination Section 15. RNA Synthesis, Processing and Regulation 36. RNA Synthesis and Regulation in Bacteria 37. Gene Expression in Eukaryotes 38. RNA Processing in Eukaryotes Section 16. Protein Synthesis and Recombinant DNA Techniques 39. The Genetic Code 40. The Mechanism of Protein Synthesis 41. Recombinant DNA Techniques