How Helminths Alter Immunity to Infection -

How Helminths Alter Immunity to Infection (eBook)

William Horsnell (Herausgeber)

eBook Download: PDF
2014 | 2014
X, 152 Seiten
Springer New York (Verlag)
978-1-4939-1489-0 (ISBN)
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Helminth infections are common, cause considerable pathology, and alter a host's immune profile. This can have important consequences not only on the host's ability to control a helminth infection, but also on their ability to control unrelated infections. In endemic areas, understanding how helminth infection influences the outcome of common infectious diseases and changes the efficacy of childhood vaccination programs is an important public health question.

This book reviews how host immunity to helminths alters our ability to respond to the major pathogens that exist in helminth endemic regions. Current understanding of how helminths alter important but relatively neglected contributors to the host's anti-helminth immune responses are addressed, namely host antibody responses and how maternal infection may alter a child's immune development. These are discussed in relation to the control of helminth infection and unrelated infections. Also covered are how helminth infections alter the host's ability to control TB, HIV and malarial infections along with neglected bacterial infections, such as cholera, and how endemic helminth infections are likely to alter our ability to respond to life-saving vaccination strategies.



William Horsnell is an immunologist at the University of Cape Town, South Africa. His research interests center on how parasitic helminth infections alter host immunity and the ability to control both the helminth and unrelated diseases.


Helminth infections are common, cause considerable pathology, and alter a host's immune profile. This can have important consequences not only on the host's ability to control a helminth infection, but also on their ability to control unrelated infections. In endemic areas, understanding how helminth infection influences the outcome of common infectious diseases and changes the efficacy of childhood vaccination programs is an important public health question.This book reviews how host immunity to helminths alters our ability to respond to the major pathogens that exist in helminth endemic regions. Current understanding of how helminths alter important but relatively neglected contributors to the host's anti-helminth immune responses are addressed, namely host antibody responses and how maternal infection may alter a child's immune development. These are discussed in relation to the control of helminth infection and unrelated infections. Also covered are how helminth infections alter the host's ability to control TB, HIV and malarial infections along with neglected bacterial infections, such as cholera, and how endemic helminth infections are likely to alter our ability to respond to life-saving vaccination strategies.

William Horsnell is an immunologist at the University of Cape Town, South Africa. His research interests center on how parasitic helminth infections alter host immunity and the ability to control both the helminth and unrelated diseases.

The Role of Antibody in Parasitic Helminth Infections.- Maternal Helminth Infections.- Helminth-M. TB Co-Infection.- Bacterial Infections and Vaccines.- Helpful or a Hindrance: Co-Infections of Helminth During Malaria.- Helminth Infections and HIV: Theories and Facts Regarding HIV and Helminth Interaction.

Erscheint lt. Verlag 24.9.2014
Reihe/Serie Advances in Experimental Medicine and Biology
Advances in Experimental Medicine and Biology
Zusatzinfo X, 152 p. 6 illus. in color.
Verlagsort New York
Sprache englisch
Themenwelt Medizin / Pharmazie Allgemeines / Lexika
Medizin / Pharmazie Medizinische Fachgebiete Mikrobiologie / Infektologie / Reisemedizin
Studium Querschnittsbereiche Infektiologie / Immunologie
Naturwissenschaften Biologie Mikrobiologie / Immunologie
Schlagworte auto-immune disease • Helminth • Infections • Infectious Diseases
ISBN-10 1-4939-1489-8 / 1493914898
ISBN-13 978-1-4939-1489-0 / 9781493914890
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