Reelin Glycoprotein -

Reelin Glycoprotein

Structure, Biology and Roles in Health and Disease

S.H. Fatemi (Herausgeber)

Buch | Softcover
443 Seiten
2014 | 2008 ed.
Springer-Verlag New York Inc.
978-1-4899-8695-5 (ISBN)
213,99 inkl. MwSt
Reelin glycoprotein is a serine protease with important roles in embryogenesis and during adult life. Reelin mutations or deficiency of the protein product could cause abnormal cortical development and reelin signaling impairment in brain. Reelin abnormalities in several neurospychiatric disorders, such as autism, schizophrenia, mood disorders and lissencephaly, may provide mechanistic explanations for etiologies of these disorders. There is also emerging data indicating the feasibility of using various medications (valproic acid, olanzapine) to increase mRNA/protein levels for reelin and/or gene therapy to prevent or treat reelin deficiencies observed in the above-mentioned disorders.


This comprehensive and integrative book examines the role that reelin plays in the etiology of various neuropsychiatric disorders, including schizophrenia and autism.

The Reelin Gene and Its Functions in Brain Development.- Apolipoprotein E Receptor 2 and Very-Low-Density Lipoprotein Receptor: An Overview.- Chemistry of Reelin.- The C-Terminal Region of Reelin: Structure and Function.- Crystal Structure of Reelin Repeats.- Comparative Anatomy and Evolutionary Roles of Reelin.- Reelin/Dab1 Signaling in the Developing Cerebral Cortex.- Ultrastructural Localization of Reelin.- Reelin and Cyclin-Dependent Kinase 5.- Reelin and the Cerebellum.- Reelin and Radial Glial Cells.- Reelin and Cognition.- Protein Kinases and Signaling Pathways that Are Activated by Reelin.- The Relationship of Oxytocin and Reelin in the Brain.- Reelin and Thyroid Hormone.- A Tale of Two Genes: Reelin and BDNF.- Reelin, Liver, and Lymphatics.- Reelin and Cajal-Retzius Cells.- Reelin and Odontogenesis.- Homozygous and Heterozygous Reeler Mouse Mutants.- Reelin and Lissencephaly.- The Role of Reelin in Etiology and Treatment of Psychiatric Disorders.- Reelin Downregulation as a Prospective Treatment Target for GABAergic Dysfunction in Schizophrenia.- Epigenetic Modulation of Reelin Function in Schizophrenia and Bipolar Disorder.- Reelin Gene Polymorphisms in Autistic Disorder.- Alzheimer’s Disease and Reelin.- Reelin and Stroke.- Reelin and Pancreatic Cancer.

Erscheint lt. Verlag 5.11.2014
Zusatzinfo XXIII, 443 p.
Verlagsort New York
Sprache englisch
Maße 155 x 235 mm
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete Neurologie
Medizin / Pharmazie Studium
Naturwissenschaften Biologie Biochemie
Naturwissenschaften Biologie Humanbiologie
Naturwissenschaften Biologie Zoologie
ISBN-10 1-4899-8695-2 / 1489986952
ISBN-13 978-1-4899-8695-5 / 9781489986955
Zustand Neuware
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