The Immunoglobulin Receptors and their Physiological and Pathological Roles in Immunity

1 Introduction to the field.- A: Physiological role of Fc receptors.- General aspects of FcR.- 2 Molecular basis for the interaction of Fc receptors with immunoglobulins.- 3 Fc receptor genetics and the manipulation of genes in the study of FcR biology.- 4 Commentary.- FcR and Ig-transport/catabolism.- 5 The polymeric immunoglobulin receptor.- 6 Multiple roles of FcRn.- 7 Commentary: The polymeric immunoglobulin receptor and the Brambell receptor: non-haematopoietic FcRs, with much to compare.- FcR and Cell activation.- 8 Signals initiated by the high affinity FcR for IgE.- 9 Phagocyte Fc receptors for IgG.- 10 Human IgA Fc receptors (Fc?R).- 11 Platelet Fc receptors for IgG and IgE.- 12 Polymorphisms of Fc?RIIIa on NK cells and macrophages.- 13 Cooperation between IgG Fc receptors and complement receptors in host defence.- 14 Commentary.- FcR and immunoregulation.- 15 Fc?R and IgG-mediated negative regulation of immune responses.- 16 Fc?R on T cells.- 17 Role of IgG and IgE FcR in antigen presentation.- 18 Structure and function of CD23.- 19 Commentary on FcR regulation of development and function of the immune system.- B: Clinical aspects of Fc receptors.- 20 The role and use of recombinant receptors in the investigation and control of antibody-induced inflammation.- 21 FcR and autoimmunity.- 22 Heparin-induced thrombocytopenia as a model for Fc?RII-mediated disease.- 23 Fc?receptor polymorphisms: clinical aspects.- 24 Soluble Fc?R, a biological perspective.- 25 Fc?R-directed immunotherapies.- 26 The rewards of conversion to ‘FcRism’.- 27 Fc receptors: historical perspectives and a look to the future.