Susanne Brakmann is head of the junior research group "Applied Molecular Evolution" at the University of Leipzig (Germany) and a Member of the Biotechnological-Biomedical Center of Leipzig. She studied Chemistry at the Technical University of Braunschweig where she received her diploma in 1988, moving afterwards to the University of Karlsruhe to work on her thesis under the supervision of Reinhold Tacke (Ph. D. 1991). She was postdoctoral fellow at the Max-Planck-Institute for Biophysical Chemistry in Göttingen where she worked with Manfred Eigen before she moved to Leipzig in 2001. She is interested in directed evolution as a tool for understanding and optimizing enzyme functions, focusing on nucleic acid polymerases and their biotechnological applications. ***** Kai Johnsson is assistant professor for Bioorganic Chemistry at the Swiss Federal Institute for Technology (EPFL) where he heads the laboratory for protein engineering. Prior to joining EPFL, he was a junior group leader at Ruhr-University Bochum in Germany, after spending three and a half years in the laboratory of Prof. Peter G. Schultz (University of California, Berkeley) as a postdoctoral research fellow. Kai Johnsson studied chemistry and did his PhD with Prof. Steven Benner at ETH Zurich. Since the start of his PhD thesis, Kai Johnsson's research interests focus on biological chemistry and in particular enzyme mechanisms and protein chemistry. Prof. Johnsson is the inventor of the Covalys technology.

Introduction
Evolutionary Biotechnology - From Ideas and Concepts to Experiments and Computer Simulations
Using Evolutionary Strategies to Investigate the Structure and Function of Chorismate Mutases
Construction of Environmental Libraries for Functional Screening of Enzyme Activity
Investigation of Phage Display for the Directed Evolution of Enzymes
Directed Evolution of Binding Proteins by Cell Surface Display: Analysis of the Screening Process
Yeast n-Hybrid Systems for Molecular Evolution
Advanced Screening Strategies for Biocatalyst Discovery
Engineering Protein Evolution
Exploring the Diversity of Heme Enzymes through Directed Evolution
Directed Evolution as a Means to Create Enantioselective Enzymes for Use in Organic Chemistry
Applied Molecular Evolution of Enzymes Involved in Synthesis and Repair of DNA
Evolutionary Generation versus Rational Design of Restriction Endonucleases with Novel Specificity
Evolutionary Generation of Enzymes with Novel Substrate Specificities