Exploring Immunology (eBook)

Gordon MacPherson is Reader in Experimental Pathology at the Sir William Dunn School of Pathology, University of Oxford and Tutor in Medicine, Oriel College Oxford. He has taught immunology to medical students for over 30 years in lectures, practical classes and tutorials at both introductory and Honours levels. He teaches all aspects of immunology, and in tutorials also covers microbiology and general pathology. His research interests are in immune regulation, particularly mucosal immunity, and the properties and roles of dendritic cells. He has published many papers (experimental and reviews) and has been an invited speaker at many international conferences Jon Austyn is Professor of Immunobiology in the Nuffield Department of Surgery at the University of Oxford. He has taught extensively in all areas of fundamental immunology over many years, and designed the MSc course in Integrated Immunology at the University of Oxford, which he now co-directs. Jon Austyn has over 25 years research experience of dendritic cell immunobiology, particularly as applied to transplantation, infectious diseases and more recently cancer. He was recently awarded with distinction the Diploma in Learning and Teaching in Higher Education by the University of Oxford.

INTRODUCTION
Introduction
Immune Responses
Infection and Immunity
Immunopathology and Immunotherapy
Exploring Immunology
THE IMMUNE SYSTEM
Introduction
Host Defence Against Infection
Anatomical Basis of Immunity
Cellular Basis of Immunity
Molecular Basis of Immunity
Immune Responses and Disease
INFECTION AND IMMUNITY
Introduction
Pathogens and Infectious Disease
Host Defence Against Infection
Infection and Immunity in Action
Immunity and Vaccines
FUNCTIONAL ANATOMY OF THE IMMUNE SYSTEM
Introduction
Natural Barriers
Functional Anatomy of Innate Immunity
Functional Anatomy of Adaptive Immunity
Development of Blood Cells and Organs of Immunity
Stem Cell and Gene Therapy
INNATE IMMUNITY
Introduction
Induction of Innate Immunity
"Tissue-Resident Cells" of Innate Immunity
Recruited Effectors of Innate Immunity
Haematopoiesis and Myeloid Cells
Vaccines and Adjuvants
T CELL-MEDIATED IMMUNITY
Introduction
Major Histocompatibility Complex and Antigen Presentation
T Lymphocyte Activation
Effector and Memory Functions of T Cells in Infection
T Cell Development and Selection
Adoptive Cell Therapy
ANTIBODY-MEDIATED IMMUNITY
Introduction
Antibody Structure and Function
B Cell Responses
B Cell Memory, Antibodies and Long-Term Resistance to Re-Infection
Cell Differentiation and Selection
Therapeutic Antibodies
IMMUNITY, DISEASE AND THERAPY
Introduction
What are the Mechanisms of Tissue Damage Caused by the Immune System?
Why Do We Make Harmful Immune Responses to Harmless Antigens?
Immunopathology and Therapy in Action
Transplantation Immunology
Tumour Immunity
Conclusions

ANSWERS TO THE QUESTIONS

FURTHER STUDY QUESTIONS