Immunopathogenesis of HIV Infection

Contens.- Introduction: Recent advances in the pathogenesis of human immunodeficiency virus infection.- Virologic and immunologic events in primary HIV infection.- The role of viral dynamics in the pathogenesis of HIV disease and implications for antiviral therapy.- Immune dysregulation and CD4+ T cell loss in HIV-1 infection.- Studies on lymphoid tissue from HIV-infected individuals: implications for the design of therapeutic strategies.- Mechanisms of resistance to HIV infection.- HIV-1-specific cytotoxic T lymphocytes and the control of HIV-1 replication.- Noncytolytic CD8 T cell-mediated suppression of HIV replication.- Role of complement and Fc receptors in the pathogenesis of HIV-1 infection.- Simian immunodeficiency virus as a model of HIV pathogenesis.