Thrombin & Singlet Oxygen (1ΔO2*) Main Factors of Hemostasis -

Thrombin & Singlet Oxygen (1ΔO2*) Main Factors of Hemostasis

Thomas Stief (Herausgeber)

Buch | Hardcover
211 Seiten
2013
Nova Science Publishers Inc (Verlag)
978-1-62808-466-5 (ISBN)
249,95 inkl. MwSt
Neutrophil granulocytes (PMN) are our primary defence cells against bacteria, fungi, parasites, or micro-thrombi. Their main weapons and signals are the reactive oxygen species (ROS), H2O2 being mother ROS, radicalic OH and non-radicalic 1 O2* being the two daughter ROS. 1 O2* is the most important ROS because it is harmful against "non-self" and harmless against "self". 1 O2* is highly reactive against S-H, S-S, or C=C groups and releases photons (h ). The activation of the assembly of their NADPH-oxidase, one main trigger (zymosan A) and one main primer (1 O2*/hv) are of great physiological and pathophysiological importance in inflammation and in hemostasis. There is photonic communication: the neutrophils generate different types of photons and they can "see" them in other cells. The approximate 300-400 nm photons are the main signals and the photons of lowest wave length seem to especially alert them in emergency.

Preface: Hemostasis Activation in Inflammation: kAllikrein, Thrombin, 1 O2*/hv; Triggering Thrombin Generation by Low Dose Dexamethasone; Modulation of Blood ROS Generation by Low Dose Dexamethasone; Modulation of Blood ROS Generation by Preincubated Low Dose Dexamethasone; Triggering Thrombin Generation by High Dose Dexamethasone; Modulation of Blood ROS Generation by High Dose Dexamethasone; Pre-Incubation Transforms Dexamethasone into a Neutrophil Stimulator; Triggering Thrombin Generation by Low Dose Hydrocortisone; Modulation of Blood ROS Generation by Low Dose Hydrocortisone; Paradoxical Increase of Blood ROS Generation by Pre-Incubated Low Dose Hydrocortisone; Reactive Oxygen Species (ROS) Generation Modulation by Prolonged Blood Incubation with Low Dose Hydrocortisone; Triggering Thrombin Generation by High Dose Hydrocortisone; Modulation of Blood ROS Generation by High Dose Hydrocortisone; Modulation of Blood ROS Generation by Pre-Incubated High Dose Hydrocortisone; Imipenem/Cilastatin at Lowest Concentrations Triggers Thrombin Generation; Imipenem/Cilastatin Inhibits the ROS Generation of Blood Neutrophils; Pre-Incubated Imipenem/Cilastatin Stimulates Blood ROS Generation; Imipenem/Cilastatin: A Pathophysiologic Trigger of Altered Matrix Coagulation; High Dose Imipenem/Cilastatin Suppresses Blood ROS Generation; Luminescence Kinetic in the Blood ROS Generation Assay (BRGA); Urate Added at Ultra-Low Concentrations (0.1 M) to Normal Plasma Triggers Thrombin Generation; Urate Triggers Thrombin Generation; Urate Inhibits ROS Generation; Urate Stimulates ROS Generation in Pre-Incubated Blood; Urate Stimulates ROS Generation in Stressed Blood; Urate Enhances Ros Generation in Pre-Incubated Oxidatively Stressed Blood; Blood Reactive Oxygen Species & Urate; Acetaminophen Suppresses the ROS Generation in Freshest Blood; Taurine Strongly Enhances the ROS Generation of Blood Neutrophils; Caffeine Modulates Blood ROS Generation; Arginine Suppresses Blood ROS Generation; Some 2-Macroglobulin/Thrombin Complexes Open by Contact Activation; Singlet Oxygen uprEgulates Neutrophils' Blue Opsin; Violet Light Upregulates Blood Opsin (OPN1SW); The Light Information Signal in Blood is Quenched by Erythrocytes; Diatrizoate/Dextran 500 (Polymorphprep (R)) Modulates Blood ROS Generation; Hydrocortisone Modulates Blue Opsin Expression on Blood Neutrophils; Acetaminophen Modulates Blue Opsin Expression on Blood Neutrophils; Pre-Incubated Metamizole Suppresses Blood ROS Generation about 10fold Stronger than Metamizole; Trigger Zymosan A Upregulates the Neutrophil's Blue Opsin; Quantification of Blood ROS Generation by Trigger Zymosan A or Primer Singlet Oxygen; Rhodopsin or UV-Opsin Upregulation in Blood by Singlet Oxygen; Index.

Verlagsort New York
Sprache englisch
Maße 180 x 260 mm
Gewicht 822 g
Themenwelt Naturwissenschaften Biologie Biochemie
Naturwissenschaften Biologie Zellbiologie
ISBN-10 1-62808-466-9 / 1628084669
ISBN-13 978-1-62808-466-5 / 9781628084665
Zustand Neuware
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