Reactive Intermediates (eBook)

Leonardo Silva Santos received is PhD from Unicamp University, Brazil, in 2003, working under the direction of Dr. A.R. Pilli. Following his PhD, Leonardo took up a postdoctoral position at the Thomson Mass Spectrometry Laboratory at the University of Campinas, where alongside Dr. M. Eberlin he established ESI-MS-based mechanistic studies in Brazil. He spent a time working as a Postdoc in the group of Jürgen Metzger at the Carl von Ossietzky University before moving to Chile. He is currently Full Professor at the Institute of Chemistry and Natural Resources at Talca University (Chile) and established the Laboratory of Asymmetric Synthesis. He is involved with the establishment of the Fraunhofer Institute in Chile and will head the chemistry group associated with the use of nanotechnology in agriculture. Professor Santos has published over 70 articles in the last four years, holds two international patents and has received numerous international honors and awards.

Preface
A BRIEF OVERVIEW OF THE MECHANISMS INVOLVED IN ELECTROSPRAY MASS SPECTROMETRY
Introduction
Production of Gas-Phase Ions by Electrospray and Electrospray Ionization Mass Spectrometry
HISTORICAL PERSPECTIVES IN THE STUDY OF ION CHEMISTRY BY MASS SPECTROMETRY: FROM THE GAS PHASE TO SOLUTION
A Brief History and Recent Advances in Mass Spectrometry
Overview of the Study of Ion/Molecule Reactions in the Gas Phase by Mass Spectrometry
Future Perspectives
ORGANIC REACTION STUDIES BY ESI-MS
Introduction
Reaction Mechanisms
General Remarks
STUDIES OF REACTION MECHANISM INTERMEDIATES BY ESI-MS
Introduction
Studies on the Intermediates and Mechanisms of Pd-Catalyzed Reactions
Studies on Some Reactive Intermediates and Mechanisms of Radical Reactions
Studies on the Intermediates and Mechanism of Organocatalysis Reactions
Studies on the Intermediates and Mechanism of Transition Metal-Catalyzed Polymerization Reactions
ON-LINE MONITORING REACTIONS BY ELECTROSPRAY IONIZATION MASS SPECTROMETRY
Introduction
Preservation of the Charge in the Transit of Ions from Solution to the Gas Phase Using the ESI Technique
Developing Methods to Study Reaction Mechanisms
Probing Reactivity of Intermediates
Conclusion
GAS PHASE LIGAND FRAGMENTATION TO UNMASK REACTIVE METALLIC SPECIES
Introduction and Scope of the Review
Unmasking Reactive Metallic Intermediates via Collision-Induced Dissociation
Conclusions
PALLADIUM INTERMEDIATES IN SOLUTION
Introduction
ESI-MS Studies in Suzuki-Miyaura Cross-Coupling and Related Reactions
ESI-MS Studies in the Identification of Oxidative Addition Intermediates
ESI-MS Studies in Mizoroki-Heck and Related Reactions
ESI-MS Studies in Stille Cross-Coupling Reactions
ESI-MS Studies in Palladium-Catalyzed Reactions Involving Allenes
ESI-MS Studies in Palladium-Catalyzed Alkynylation Reactions
ESI-MS Studies in Palladium-Catalyzed Allylic Substitution Reactions
ESI-MS Studies in Palladium-Catalyzed Oxidation of 2-Allylphenols
ESI-MS Studies in Palladium-Catalyzed Polymerization Reactions
Conclusions
PRACTICAL INVESTIGATION OF MOLECULAR AND BIOMOLECULAR NONCOVALENT RECOGNITION PROCESSES IN SOLUTION BY ESI-MS
Introduction
Methods and Applications
Practical Aspects of Titration Analysis
Summary and Outlook