Advances in Enzyme Regulation

Part 1 Enzymes in neoplasia, carcinogenesis and resistance: use of nucleoside kinase-deficient mouse leukemia L1210 cell lines to determine metabolic routes of activation of antitumor nucleoside analogs, A.H. Cory and J.G. Cory; heterogeneous (positional) expression of hepatic glutamine synthetase - features, regulation and implications for hepatocarcinogenesis, R. Gebhardt et al. Part 2 Enzymes as targets: modulation of target enzyme associated with the action of antifolates, Y.M. Rustum et al; targeted and non-targeted action of anticancer drugs, G. Weber and N. Prajda. Part 3 Regulation of IMP dehydrogenase: inosine-5'-monophosphate dehydrogenase activity is maintained in immortalized murine cells growth-arrested by serum deprivation, P.B. Stadler et al; pharmacodynamics of the inhibition of GTP synthesis in vivo by mycophenolic acid, T.J. Franklin and W.P. Morris. Part 4 Oncogene targeting and signalling: lipid-dependent nuclear signalling - morphological and functional features, N.M. Maraldi et al. Part 5 Enzymes, receptors and cell regulation: mechanism and regulation of antigen processing by cathepsin B, N. Katunuma et al; a genetic analysis of processes regulating cytochrome P4501A1 expression, O. Hankinson. Part 6 Enzymes in growth control: serine/threonine phosphatases in the control of cell function, A. Depaoli-Roach et al; human casein kinase II - structures, genes, expressions and requirement in cell growth stimulation, W. Pyerin. Part 7 Suppressor activity and transformation: molecular cloning and characterization of a cDNA showing tumor-suppressive activity in v-src transformed 3Y1 rat fibroblasts, S. Sakiyama et al; role of protein kinase C in ras-mediated fos expression, F. Uberall et al. Part 8 Protein conformation and regulation: predicting the conformation of proteins from sequences - progress and future progress, S.A. Benner et al; the multifunctional role of hormone-sensitive lipase in lipid metabolism, S.J. Yeaman et al. Part 9 Export pumps and glycoproteins: ATP-dependent export pumps and their inhibition by cyclosporins, M. Bohme et al; the mammalian UV response, P. Herrlich et al. Part 10 Special symposium lecture: the methotrexate story - a paradigm for development of cancer chemotherapeutic agents, F.M. Huennekens. (Part Contents).