Therapeutic Targets (eBook)

Luis M. Botana was Director of the Department of Pharmacology at the University of Santiago de Compostela (USC), Director of the European Union Reference Laboratory for Marine Biotoxins, and scientific advisor to the drug company LCIFGA. The author of 200 papers and 15 patents, Dr. Botana is the editor of several other books, including Phycotoxins: Chemistry and Biochemistry, published by Wiley (2007). Mabel Loza is Professor of Pharmacology at the University of Santiago de Compostela (USC). She created the USEF Drug Screening Platform, with more than ten years of experience in public and private mixed early drug discovery programs.

Preface vii

Contributors ix

1. cAMP-Specific Phosphodiesterases: Modulation, Inhibition, and
Activation 1

R. T. Cameron and George S. Baillie

2. Protease-Activated Receptor 2 37

Qihai Gu and Lu-Yuan Lee

3. Voltage-Gated Sodium Channels as Therapeutic Targets 63

Joshua S. Wingerd, Irina Vetter, and Richard J. Lewis

4. Multitarget Drugs for Stabilization of Calcium Cycling and
Neuroprotection in Neurodegenerative Diseases and Stroke 123

Antonio M. G. de Diego, Silvia Lorrio, Jesús M.
Hernández-Guijo, Luis Gandía, and Antonio G.
García

5. Oligomerization of G-Protein-Coupled Receptors 201

Juan F. López-Giménez and Javier
González-Maeso

6. Sigma 1 Receptor Chaperone: Pharmacology and Therapeutic
Perspectives 225

Daniel Zamanillo, Enrique Portillo-Salido, José Miguel
Vela, and Luz Romero

7. Lipids as New Targets 279

Eduardo Domúnguez

8. Knowledge Base for Nuclear Receptor Drug Discovery 309

Albert A. Antolín and Jordi Mestres

9. Gene Promoters and Transcription Control Regions as
Therapeutic Targets 327

Antonio Zorzano, David Sebastian, Jana Sánchez-Wandelmer,
Laia Miret, and Fernando Albericio

10. Roles of Glucagon-Like Peptide and Glucose-Dependent
Insolinotropic Polypeptide Hormones in Brain Function and
Neurodegeneration 351

Christian Hölscher

11. Exocytotic Machinery as a Target for the Development of New
Drugs for Schizophrenia 375

María Jose Guerrero, Itsaso Hormaeche, María
Uribarri, Julie Masse, and José María Palacios

12. Targeting Epigenetic Abnormalities in the Brain 409

Erin Y. Sterner, Lisa E. Kalynchuk, and Hector J.
Caruncho

13. Rodent Models as Tools for Discovering Novel Therapeutic
Targets in the Brain: The Case of Epilepsy 427

Justin J. Botterill, Axel J. Guskjolen, Lisa E. Kalynchuk, and
Hector J. Caruncho

14. New Approaches Applied to Drug Screening 455

José Brea and María Isabel Loza

Index 477

"In summary, there are a number of well-written and
constructed, comprehensive monographs that will be of interest to
experts." (ChemMedChem, 1 March 2013)

"The degree to which an integrated, unified, and visionary
perspective emerges across the book is limited. Nonetheless,
individual chapters are likely to be very useful to readers in that
specific research area. The book certainly offers descriptions of
several active target development approaches and application of
such approaches in specific biological systems."
(Doody's, 1 March 2013)