Mucus Hypersecretion in Respiratory Disease (eBook)

Derek J. Chadwick and Jamie A. Goode are editors for Mucus Hypersecretion in Respiratory Disease and other scientific titles.

Chair's Introduction (C. Basbaum).

Epidemiological studies in mucus hypersecretion (J. Vestbo).

Post-secretory fate of host defence components in mucus (M.
Salathe, et al.).

Mechanisms of submucosal gland morphogenesis in the airway (M.
Filali, et al.).

Mucin-producing elements and inflammatory cells (P. Jeffery and
J. Zhu).

Respiratory tract mucins: structure and expression patterns (J.
Davies, et al.).

Development and validation of a lectin-based assay for the
quantitation of rat respiratory mucin (A. Jackson, et al.).

Regulation of mucin secretion from in vitro cellular
models (C. Davis).

Oscillations of pH inside the secretory granule control the gain
of Ca¯2+ release for signal transduction in goblet cells
exocytosis (W. Chin, et al.).

A calcium-activated chloride channel blocker inhibits goblet
cell metaplasia and mucus overproduction (Y. Zhou, et al.).

Mechanisms by which Gram-positive bacteria and tobacco smoke
stimulate mucin induction through the epidermal growth factor
receptor (EGFR) (C. Basbaum, et al.).

Non-allergic models of mu cous cell metaplasia and mucus
hypersecretion in rat nasal and pulmonary airways (J. Harkema and
J. Wagner).

Cytokine regulation of mucus production in a model of allergic
asthma (L. Cohn, et al.).

The role of apoptotic regulators in metaplastic mucous cells (Y.
Tesfaigzi).

Current and future therapies for airway mucus hypersecretion (P.
Barnes).

Clinical evaluation of new therapies for treatment of mucus
hypersecretion in respiratory diseases (B. Disse).

Final general discussion.

Index of contributors.

Subject index.

"...I would recommend this book to both basic and clinical scientists..." (European Respiratory Journal)