Basic Pharmacology

MARIA A. HERNANDEZ, Ph.D. has a proven track record in organic synthesis, medicinal chemistry, biochemistry, and in process and product development. She is creative, team-oriented, results-driven, and a strong problem solver. She has vast experience in industrial chemicals and pharmaceuticals bulk manufacturing under cGMP and has managed validation projects in Chemical and Pharmaceutical Plants and led multidisciplinary teams for Total Quality Management projects. She has authored seven chapters in a Pharmacology book and is currently dedicated to teaching medicinal chemistry at the University level. Her research interests include the synthesis of serine protease and protein kinase inhibitors as therapeutic agents and the study of Phenylalanine in signaling pathways.

Preface. The Authors. Physicochemical Properties of Drugs. Fundamental Chemical Properties of Drugs. Acid-Base Properties of Drugs. Structural Determinants of Drug Action. Chemical Approaches to the Treatment of Cancer. Principles of Biopharmaceutics. Drug Administration and Absorption. Drug Distribution and Elimination. Metabolic Changes of Drugs. Principles of Drug-Receptor and Drug-Enzyme Interactions. Drug Receptors and Pharmacodynamics. Drug Induced Enzyme Inhibitions. Dopaminergic and Anti-Histamine Systems. Drug-Receptor Dynamics and Theories. Receptor Regulation and Signaling Mechanisms. Principles of Pharmacogenomics. Genetic Basis for Variations in Drug Response. Targeted Cancer Therapies. About the Author.