Solving Problems in Genetics

Richard Kowles (Autor)

Buch | Softcover

479 Seiten

2001 | Softcover reprint of the original 1st ed. 2001
Springer-Verlag New York Inc.
978-0-387-98841-2 (ISBN)

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The principle objective of this book is to help undergraduate students in the analysis of genetic problems. Many students have a great deal of difficulty doing genetic analysis, and the book will be useful regardless of which genetics text is being used. Most texts provide some kinds of problems and answers: few, if any, however, show the students how to actually solve the problem. Often the student has no idea how the answer was derived. This work emphasizes solutions, not just answers. The strategy is to provide the student with the essential steps and the reasoning involved in conducting the analysis. Throughout the book, an attempt is made to present a balanced account of genetics. Topics, therefore, center about Mendelian, cytogenetic, molecular, quantitative, and population genetics, with a few more specialized areas. Whenever possible the student is provided with the appropriate basic statistics necessary to make some of the analyses. The book also builds on itself; that is, analytical methods learned in early parts of the book are subsequently revisited and used for later analyses. A deliberate attempt is made to make complex concepts simple, and sometimes to point out that apparently simple concepts are sometimes less so on further investigation. Any student taking a genetics course will find this book an invaluable aid to achieving a good understanding of genetic principles and practice.

1 Mendelism.- Basic Probability: Methods for Analyzing Mendelian Genetics.- Forked Line Method.- Mendel’s Data.- Crosses Involving Three or More Gene Pairs.- Goodness of Fit Testing.- Subdividing Chi Square.- Gene Interaction.- Distinguishing Among Genetic Ratios.- Double Fertilization in Plants.- Additional Plant Genetics Considerations.- Problems.- Solutions.- Reference.- 2 Sex Determination and Sex Linkage.- General Aspects of Mating Systems.- XX/XY Chromosome System.- Sex Ratios.- Binomial Statistics.- Haploid-Diploid Sex Determination.- Sex Linkage.- Pedigrees.- Partial Sex-Linkage.- Problems.- Solutions.- 3 Chromosomes and Cell Division.- Chromosomes.- The Cell Cycle.- Further Analysis of the Cell Cycle.- Percent Labeled Mitoses Method.- Mitosis.- Meiosis.- Genetic Diversity.- C Values.- Problems.- Solutions.- 4 Linkage, Recombination, and Mapping.- Exceptions to Independent Assortment.- Recombination Values and Genetic Maps.- Three-Point Tests.- Mapping Concepts.- Recombination Calculated with F2 Data.- Haploid Genetics.- Tetrad Analysis.- Tetrad Analysis and Gene Mapping.- Problems.- Solutions.- Reference.- 5 Variations in Chromosome Number and Structure.- Types of Chromosome Variation.- Aneuploidy.- Polyploidy.- Deletions and Duplications.- Inversions.- Translocations.- Other Aberrations.- Problems.- Solutions.- 6 Quantitative Inheritance.- Continuous Variation.- Polygenes.- Estimating Number of Gene Pairs Involved in Quantitative Traits.- Variance.- Broad Sense Heritability.- Narrow Sense Heritability.- Heterosis.- Thresholds.- Mapping Quantitative Traits.- Problems.- Solutions.- Reference.- 7 Population Genetics.- Concept of Gene Pools.- Gene and Genotype Frequencies.- Hardy-Weinberg Principle.- Hardy-Weinberg Equilibrium.- Extensions of Hardy-WeinbergRelationships.- Genetic Drift.- Migration.- Mutation.- Selection.- A Statistical Approach to Change in a Population.- Nonrandom Mating.- Problems.- Solutions.- References.- 8 Gene Concepts.- One-Gene One-Enzyme.- Allelism.- Bacterial Genetics.- Bacteriophages.- Complementation.- Genetic Fine Structure Analysis in Bacteriophages.- Genetic Fine Structure Analysis in Other Organisms.- Problems.- Solutions.- References.- 9 Molecular Basis of Heredity.- Nucleic Acids.- Nearest Neighbor Frequency Analysis.- Central Dogma.- Semiconservative Mode of Replication.- Replication Forks and Okazaki Fragments.- Transcription.- Proteins.- Translation.- Genetic Code.- Regulation.- Operon Systems.- Mutation.- Mutation Detection.- Problems.- Solutions.- References.- 10 Non-Mendelian Inheritance.- Cytoplasmic Inheritance.- Male Sterility in Plants.- Maternal Effects.- Genomic Imprinting.- DNA Trinucleotide Repeats.- Meiotic Drive.- B Chromosomes.- Problems.- Solutions.- 11 Human Genetics.- Mendelian Inheritance in Humans.- Bias of Ascertainment.- Epidemiology and Pedigrees.- Linkage Analysis—Classical Approaches.- Physical Mapping.- Human Genome Project.- Population Genetics.- Testing Inheritance of a Single Allelic Pair in a Population.- Consanguinity.- Methods of Studying the Genetic Basis of Behavior in Humans.- Twin Studies and Concordance.- Problems.- Solutions.- References.- 12 Additional Genetic Analysis Using Statistics.- More Probability.- Permutations and Combinations.- The Binomial Distribution.- Poisson Distribution.- Contingency Tables—Test for Independence.- Problems.- Solutions.

Zusatzinfo	34 Illustrations, black and white; XV, 479 p. 34 illus.
Verlagsort	New York, NY
Sprache	englisch
Maße	178 x 235 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete
	Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik
	Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
	Naturwissenschaften ► Biologie ► Zellbiologie
ISBN-10	0-387-98841-6 / 0387988416
ISBN-13	978-0-387-98841-2 / 9780387988412
Zustand	Neuware