Biological Reaction Engineering

Irving J. Dunn is retired from the ETH-Zurich, where he taught and did research in the area of biochemical engineering for over thirty years, within the Chemical Engineering Dept. His degrees are from the University of Washington and Princeton University. Dr. Dunn has published widely in his field, ranging from bioreactor design, process control, animal cell culture, and specialized wastewater treatment. His teaching and research has featured the use of modelling and simulation and has resulted in the publication of three textbooks: Biological Reaction Engineering, Environmental Bioprocesses and Chemical Engineering Dynamics. Elmar Heinzle is the Chair of Biochemical Engineering at the Saarland University in Saarbrucken, Germany. Having obtained his academic degrees from the Technical University of Graz, Austria, he spent most of his career at the Chemical Engineering Department of ETH-Zurich, Switzerland, before taking his present appointment. Professor Heinzle published over 200 scientific publications in bioreactor design, metabolic engineering, on-line analysis and control and design of sustainable processes. In his teaching in Biochemical and Chemical Engineering he is extensively using modelling. He has authored several books in these fields. John Ingham is now retired from Chemical Engineering at Bradford University U.K. The first of a long series of courses on the Modelling and Simulation of Dynamical Chemical Engineering Systems was begun there in 1974, sponsored by the Institution of Chemical Engineers and inspired by leave of absence at the ETH Zurich. Research areas include Liquid-Liquid Column Hydrodynamics, Extraction Process Dynamics and Biochemical Engineeering; the latter, being developed, during a further leave of absence at the GBF, Braunschweig. He is especially proud of this and the two other VCH-Wiley Modelling and Simulation books. Jiri E. Prenosil was born 1939 in Prague, Czechoslovakia. Educated in Prague with PhD in Chemical Engineering, he worked in the Czechoslovak Academy of Science and various universities abroad. 1971 he moved to Switzerland with appointment at the Swiss Federal Institute of Technology (ETH) in Zurich. 1984 he was a Visiting Professor at the University of London, Canada. His life interest is in Biochemical Engineering, design and modelling of bioreactors with immobilized biocatalysts. It has resulted in over 100 publications and co-authorship of two other books in this area. He is a co-founder of the renowned International Modelling and Simulation Courses in Braunwald, Switzerland since 1981. 1997 he was granted the Swiss Technology Transfer Award. In 2006, he retired from the ETH.

Part I Principles of Bioreactor Modeling
Modeling Principles
Basic Bioreactor Concepts
Biological Kinetics
Bioreactor Modeling
Mass Transfer
Diffusion and Biological Reaction in Immobilized Biocatalyst Systems
Automatic Bioprocess Control Fundamental
Basic Cell and Bioreactor Models
Part II Dynamic Bioprocess Simulation Examples Using the BERKELEY MADONNA Simulation Language
Biological Reaction Process Modeling Examples
Simulation Examples of Biological Reaction Processes Using BERKELEY MADONNA
Appendix: Using the Berkeley Madonna Language and Accessing the Simulation Examples

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C. Posten, Karlsruhe
CIT 3/04

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Chemie Ingenieur Technik, B. Nienhaus, Frankfurt