Adherens Junctions: from Molecular Mechanisms to Tissue Development and Disease

1. An introduction to adherens junctions: from molecular mechanisms to tissue development and disease. - Part I: How AJs evolved. - 2. Evolution of the cadherin-catenin complex. - Part II: How cadherins and catenins interact to assemble AJs. - 3. The three-dimensional structure of the cadherin-catenin complex. - 4. Biophysics of cadherin adhesion. - 5. Adherens junction assembly. - Part III: How AJs interface with other cellular machinery. - 6. The cytoskeleton and classical cadherin adhesions. - 7. Immunoglobulin superfamily receptors and adherens junctions. - 8. Signaling from the adherens junction. - 9. Adherens junction turnover: regulating adhesion through cadherin endocytosis, degradation, and recycling. - Part IV: How AJs affect cell behaviour and multicellular development. - 10. Adherens junctions during cell migration. - 11. Adherens junctions and cadherins in Drosophila development. - 12. Adherens junctions in C. elegans embryonic morphogenesis. - 13.Cadherin function during Xenopus gastrulation. - 14. Adherens junctions in mammalian development, homeostasis and disease: lessons from mice. - Part V: How AJs affect tissue homeostasis and disease. - 15. Adherens junctions and stem cells. - 16. Adherens junctions and cancer. - 17. Adherens junctions and pathogens entry.