Metals in Biology

Prof. Graeme Hanson, located in the Centre for Magnetic Resonance at the University of Queensland, has applied a unique synergistic approach involving both theoretical and experimental aspects of multifrequency continuous wave and pulsed EPR spectroscopy to structurally (geometric and electronic) characterise the metal binding sites in metalloenzymes and transition metal ion complexes. The development and commercialisation of the XSophe-Sophe-XeprView (CW EPR) and Molecular Sophe(CW EPR, Pulsed EPR and ENDOR) computer simulation software suites has been crucial in the characterisation of these biological inorganic systems. Dr. Lawrence J. Berliner is currently at the Department of Chemistry and Biochemistry, University of Denver, where he was Professor and Chair for the past 8 years. He retired from The Ohio State University, where he spent a 32-year career in the area of biological magnetic resonance (EPR and NMR). He has been recognized by the International EPR Society with the Silver Medal for Biology/Medicine in 2000. He also received the Lifetime Achievement Award in Biological EPR Spectroscopy at EPR-2005. He is the Series Editor for Biological Magnetic Resonance, which he launched in 1979.

IRON–SULFUR-CONTAINING PROTEINS.- Electron Magnetic Resonance of Iron#x2013;Sulfur Proteins in Electron-Transfer Chains: Resolving Complexity.- Catalysis and Gene Regulation.- Iron#x2013;Sulfur Clusters in #x201C;Radical SAM#x201D; Enzymes: Spectroscopy and Coordination.- MONONUCLEAR MOLYBDENUM ENZYMES.- EPR Studies of Xanthine Oxidoreductase and Other Molybdenum-Containing Hydroxylases.- High-Resolution EPR Spectroscopy of Mo Enzymes. Sulfite Oxidases: Structural and Functional Implications.- Dimethylsulfoxide (DMSO) Reductase, a Member of the DMSO Reductase Family of Molybdenum Enzymes.- MANGANESE-CONTAINING ENZYMES.- The Manganese-Calcium Cluster of the Oxygen-Evolving System: Synthetic Models, EPR Studies, and Electronic Structure Calculations.- Manganese Metalloproteins.- NOVEL METALLOENZYMES AND METALLOPROTEINS.- EPR of Cobalt-Substituted Zinc Enzymes.- Hyperfine and Quadrupolar Interactions in Vanadyl Proteins and Model Complexes: Theory and Experiment.