The Migraine Brain

David Borsook, MD, PhD Director, Pain & Analgesia Imaging Neuroscience (P.A.I.N.) Group McLean Hospital, Masschusetts General Hospital, and Children's Hospital Belmont, MA Arne May, MD, PhD Institut für Systemische Neurowissenschaften Zentrum für Experimentelle Medizin Universitätsklinikum Hamburg-Eppendorf Hamburg, Germany Peter Goadsby, MD, PhD Director, UCSF Headache Center Department of Neurology University of California, San Francisco San Francisco, CA Richard Hargreaves, PhD Vice President Worldwide Discovery Head Neuroscience Merck Research Laboratories West Point PA and Kenilworth, NJ

I. Migraine: History ; Chapter 1: A History of Migraine, Mervyn Eadie ; II. Neurobiology of the Migraine Brain ; Chapter 2: Migraine - Some Theories and Controversies, Farooq Maniyar and Peter J. Goadsby ; Chapter 3: Neural System Changes in Migraine, Peter D. Drummond ; Chapter 4: Sensitization of Trigeminovascular Pathway: Implications to Migraine Pathophysiology, Rami Burstein and David Borsook ; Chapter 5: Brain Measures of the Interictal Migraine Brain State (IMBS), Nasim Maleki, Lino Becerra, and David Borsook ; Chapter 6: From Episodic to Chronic Migraine, Richard B. Lipton and Marcelo E. Bigal ; Chapter 7: Concomitant Symptoms in Migraine, Arne May & Anne Stankewitz ; III. Clinical Perspective ; Chapter 8: Clinical Neuroimaging of Migraine, Randolph W. Evans ; Chapter 9: Prophylaxis: What Measures?, Stephen Silberstein ; Chapter 10: Iron Accumulation in Migraine, Inge H. Palm-Meinders, Michel D. Ferrari, Mark C. Kruit ; Chapter 11 : Migraine and Brain Lesions, Inge H. Palm-Meinders, Michel D. Ferrari, Mark C. Kruit ; Chapter 12: Clinical Utility of Objective Measures, Franz Riederer, Andreas R. Gantenbein & Peter S. Sandor ; Chapter 13: Migraine Genes - Clinical and Preclinical Perspectives, Claudia M. Weller, Boukje de Vries, Gisela M Terwindt, Michel D. Ferrari, Joost Haan, and Arn M.J.M. van den Maagdenberg ; IV. Imaging Migraine ; Chapter 14: Imaging migraine: A history, Jes Olesen and Peer Tfelt-Hansen ; Chapter 15: Focus on the Midbrain, Hans-Christoph Diener, Arne May ; Chapter 16: Diffusion Weighted Imaging in Migraine, Christos Sidiropoulos and Panayiotis D. Mitsias ; Chapter 17: DIFFUSION TENSOR IMAGING ABNORMALITIES IN MIGRAINE, ; Maria A. Rocca and Massimo Filippi ; Chapter 18: Morphometric changes and VBM, Arne May ; Chapter 19: SURFACE-BASED STRUCTURAL CHANGES IN MIGRAINE, Cristina Granziera ; Chapter 20: Changing receptors in Migraine state, Genevieve Demarquay and Francois Mauguiere ; Chapter 21: 15O PET studies in migraine, Marie Denuelle, Pierre Payoux, Nelly Fabre and Gilles Geraud ; Chapter 22 : Imaging activation in the migraine state, Till Sprenger, Christian Seifert, Peter J. Goadsby ; Chapter 23: Metabolites and migraine, Caterina Tonon, Giulia Pierangeli, Sabina Cevoli, Pietro Cortelli, Raffaele Lodi ; Chapter 24: Visual aura, Nouchine Hadjikhani, Maurice B. Vincent ; Chapter 25: Functional Imaging of the Migraine Brain: New Insights into Brain Dysfunction, Eric A. Moulton ; Chapter 26: TMS and MEG studies in migraine, Sheena K Aurora, Sidra Saeed, and Susan M Bowyer ; Chapter 27: Magnetic Resonance Angiography and Migraine, M. Sohail Asghar and Messoud Ashina ; Chapter 28: Transcranial Magnetic Stimulation (TMS) / Repetitive Transcranial Magnetic Stimulation (rTMS), Magdalena Sarah Volz and Felipe Fregni ; Chapter 29: Measures of cortical excitability, Gianluca Coppola and Jean Schoenen ; Chapter 30: Drug Effects on Cortical Excitability, Susan M. Bowyer and Panayiotis D. Mitsias ; V. Conclusions ; Chapter 31: Defining the Migraine Phenotype, Todd J. Schwedt and David W. Dodick ; Chapter 32: The Future of Imaging in Migraine Diagnosis and Treatment, David Borsook and Lino Becerra ; Chapter 33: Can Imaging Effectively Transform Migraine Treatment?, David Borsook, Arne May, Peter Goadsby, Richard Hargreaves