Drug Metabolism (eBook)

Drug Metabolism In Context: Introduction.- Absorption.- Drug Distribution.- Dynamics Of Drug Action.- 5 Drug Clearance.- Dynamics Of Drug Clearance.- Pathways Of Biotransformation – Phase I Reactions: Introduction.- Phase I And Phase II Metabolism: General Considerations.- Oxidations Involving The Microsomal Mixed-Function Oxidase System.- Oxidations Involving Other Enzymatic Systems.- Metabolic Reactions Involving Reduction.- Hydrolysis.- Miscellanous Phase I Reactions.- The Fate Of Phase I Reaction Products.- Pathways Of Biotransformation – Phase II Reactions: Introduction.- Glucuronidation.- Acetylation.- Glutathione Conjugation.- Other Conjugative Reactions.- Concluding Remarks.- Enzymatic Systems Involved In Drug Biotransformation: Ntroduction.- Interaction Between A Drug Substrate And An Enzyme.- Enzyme Systems With Specific Roles.- Final Remarks.- Induction And Inhibition Of Drug-Metabolising Enzymes.- Introduction.- Induction.- Inhibition.- Consequences Of The Above Phenomena.- Dietary And Non-Dietary Factors In Enzyme Induction And Inhibition.- Factors That Influence Drug Biotransformation.- Introduction.- Intrinsic Factors.- Environmental Factors.- Further Observations.- Impact Of Gene Variability On Drug Metabolism.- Introduction.- Basic Principles Of Pharmacogenetics.- Pharmaco-Informatics.- Implications For Third Millennium Medicine.- Drug Interactions And Adverse Reactions: Introduction.- Drug-Drug Interactions.- Interactions Between Drugs And Other Entities.- Adverse Reactions.- Summary.- Strategies For Drug Design.- Introduction.- Pharmacokinetics And Metabolism In Drug Research.- The Role Of Formulation.- Concluding Remarks.- Index.